Registration Dossier
Registration Dossier
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EC number: 200-659-6 | CAS number: 67-56-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Test substance applied as 50 % aqueous solution, postobservation period only 7 days
- Principles of method if other than guideline:
- Study was performed before actual guideline was adopted. BASF-test.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 %
- Amount of vehicle (if gavage): 3.2 ml/kg
MAXIMUM DOSE VOLUME APPLIED: 6.4 ml/kg - Doses:
- 2528 mg/kg bw (6.4 ml/kg)
- No. of animals per sex per dose:
- 10 (sex not specified)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- >= 2 528 mg/kg bw
- Remarks on result:
- other: application as 50% aqueous solution
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: Staggering, narcotic effects.
- Gross pathology:
- no data
- Other findings:
- - Potential target organs: CNS
Applicant's summary and conclusion
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