Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1961
Report Date:
1961

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
Test substance applied as 50 % aqueous solution, postobservation period only 7 days
Principles of method if other than guideline:
Study was performed before actual guideline was adopted. BASF-test.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 50 %
- Amount of vehicle (if gavage): 3.2 ml/kg

MAXIMUM DOSE VOLUME APPLIED: 6.4 ml/kg
Doses:
2528 mg/kg bw (6.4 ml/kg)
No. of animals per sex per dose:
10 (sex not specified)
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD0
Effect level:
>= 2 528 mg/kg bw
Remarks on result:
other: application as 50% aqueous solution
Mortality:
No mortality occurred.
Clinical signs:
Staggering, narcotic effects.
Body weight:
no data
Gross pathology:
no data
Other findings:
- Potential target organs: CNS

Applicant's summary and conclusion