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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: poisoning incident
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Ocular manifestations and complications of acute methyl alcohol intoxication.
Author:
Dethlefs, R. and Naraqi, S.
Year:
1978
Bibliographic source:
Med J Australia 2: 483-485

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
neurotoxicity
Principles of method if other than guideline:
The ocular manifestations of acute methyl alcohol intoxication were studied in 24 men during an outbreak.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Subjects:
- Number of subjects exposed: 24
- Sex: male
- Race: Papua New Guinean
Route of exposure:
oral
Reason of exposure:
intentional
Exposure assessment:
estimated

Results and discussion

Results of examinations:
Three groups were identified: Nine patients had no ocular abnormality, 7 had only transient ocular abnormalities, and eight had permanent ocular abnormalites.
Transient abnormalities included peripapillary oedema, optic disc hyperemia, diminished pupillary reactions to light, and central scotomata.
Permanent ocular abnormalities included optic disc pallor, attenuation of arterioles, sheathing of arterioles, diminished pupillary reaction to light, diminished visual acuity, central scotomata, and other nerve fibre bundle defects.
Complete blindness occurred in two patients, while severe visual deficit resulted in four others.
The incidence of permanent ocular abnormalities was found to correlate with the incidence of metabolic acidosis (p<0.01), and with the stated volume of methanol consumed (p<0.05). An inverse correlation was found between stated volume of methanol consumed and onset of blurred vision.

Applicant's summary and conclusion