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Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Human workplace investigations, published in peer reviewed literature. Limitations in reporting but otherwise adequate for assessment and used as supporting data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
High production volume challenge revised test plan for acetylene CAS NO. 74-86-2
Author:
American Chemistry Council Acetylene Panel
Year:
2006
Bibliographic source:
http://www.epa.gov/HPV/pubs/summaries/acetylen/c15005rt2.pdf
Reference Type:
other: Publication cited in ACCAP review 2006
Title:
Epidemiologic problems associated with exposure to several agents
Author:
Waxweiler RJ
Year:
1981
Bibliographic source:
Environ Health Perspect 42: 51-56
Reference Type:
other: Publication cited in ACCAP review 2006
Title:
No title identified
Author:
Riboli E
Year:
1988
Bibliographic source:
Scand J Environ Health 9:455-462
Reference Type:
other: Publication cited in ACCAP review 2006
Title:
Preliminary report of an exposure-based, case-control monitoring system for discovering occupational carcinogens
Author:
Siemiatycki J
Year:
1982
Bibliographic source:
Teratog Carcinog Mutagen 2(2): 169-177
Reference Type:
other: Publication cited in ACCAP review 2006
Title:
Mortality of workers at acetylene production plants
Author:
Newhouse ML
Year:
1988
Bibliographic source:
Br J Ind Med 45:63-69
Reference Type:
other: Publication cited in ACCAP review 2006
Title:
Cancer mortality among Danish molders
Author:
Hansen ES
Year:
1991
Bibliographic source:
Am J Ind Med 20:401-409
Reference Type:
other: Publication cited in ACCAP review 2006
Title:
Toxic substance exposure and multiple myeloma: a case-control study
Author:
Morris PD
Bibliographic source:
J Natl Cancer Inst. 76(6):987-994
Reference Type:
other: Publication cited in ACCAP review 2006
Title:
Infectious and noninfectious exposures in the etiology of light chain myeloma: a case-control study
Author:
Williams AR
Year:
1989
Bibliographic source:
Cancer Res. 49:4038-4041
Reference Type:
other: OTS report cited in ACCAP review 2006
Title:
No title identified
Author:
Rohm and Haas Company
Year:
1980
Bibliographic source:
OTS0518103 and OTS0518118 (TSCATS/402048, 402078)

Materials and methods

Endpoint addressed:
carcinogenicity
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Method

Ethical approval:
not specified
Details on study design:
The review article summarises data from numerous studies involving occupational exposure to acetylene
Exposure assessment:
not specified

Results and discussion

Results:
Acetylene has been used for over 100 years as an anesthetic and industrial chemical, and few complications of using this gas have been reported, published epidemiological studies have failed to establish a link between use of acetylene and cancer (see endpoint summary for further details).

Applicant's summary and conclusion

Conclusions:
Numerous studies of exposed workers have failed to establish any link between acetylene and cancer.
Executive summary:

The American Chemistry Council Acetylene Panel reviewed the material in December 2006. They recognised acetylene has been used for over 100 years as an anesthetic and industrial chemical, and few complications of using this gas have been reported, published epidemiological studies have failed to establish a link between use of acetylene and cancer. Waxweiler, 1981 found no evidence of any association with liver angiosarcoma in workers exposed to a number of materials. Acetylene exposure was not a risk factor in mortality from lung cancer in a case-referent study in which exposure to chemicals in an acetylene and phthalic anhydride plant accounted for one third of the total number of lung cancer deaths (Riboli et al., 1988). A pilot study on 454 men found no association between occupational exposure to acetylene and the development of cancer (Siemiatycki et al., 1982). A study of 370 workers involved in acetylene cylinder manufacture between 1935 -1975, reported excess mortality from lung cancer, and cancer of the stomach and pancreas. However, no association between exposure to acetylene and lung cancer was identified (Newhouse et al., 1988). Acetylene also was not listed as a risk factor for developing cancer in a study of 632 Danish male molders (Hansen, 1991). In two case-controlled studies, acetylene exposure was not identified as a risk factor for developing multiple myeloma (Morris et al., 1986; Williams et al., 1989). In 1980 Rohm and Haas reported the findings of a Texas plant, which utilizes acetylene and other chemicals to produce acrylate and methacrylate ester, the excess of total cancer deaths in those hired from 1958 to 1962, could not be correlated with job-related causes.