Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

Acetylene is a simple asphyxiant.  No evidence of systemic toxicity were seen in humans following acute inhalation exposure up to one hour to concentrations up to 100,000 ppm (107,000 mg/m3), the only symptom being a feeling of mild intoxication (Davidson, 1925). Furthermore there was no indication of any local irritant effects. Acetylene does not present an acute hazard following inhalation and is not classified under CLP, hence there is no requirement to propose an acute DNEL.

Chronic exposure of rats and mice to acetylene at 20 ppm (21.4 mg/m3) for 18 and 12 months respectively had no effect on survival and no evidence of carcinogenicity. Acetylene was tested as a control in that study because it was use as stabilizing agent for the test substance. Therefore the study is not adequate for DNEL derivation but gives a weight of evidence that no chronic effect is to be expected from low concentrations of acetylene.

There is no evidence of irritation following acute exposure, and indeed the use of acetylene as an asphyxiant supports this, thus there is no proposal for a short-term DNEL, nor DNEL for systemic effects.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

Acetylene is a simple asphyxiant.  No evidence of systemic toxicity were seen in humans following acute inhalation exposure up to one hour to concentrations up to 100,000 ppm (107,000 mg/m3), the only symptom being a feeling of mild intoxication (Davidson, 1925). Furthermore there was no indication of any local irritant effects. Acetylene does not present an acute hazard following inhalation and is not classified under CLP, hence there is no requirement to propose an acute DNEL.

Chronic exposure of rats and mice to acetylene at 20 ppm (21.4 mg/m3) for 18 and 12 months respectively had no effect on survival and no evidence of carcinogenicity. Acetylene was tested as a control in that study because it was use as stabilizing agent for the test substance. Therefore the study is not adequate for DNEL derivation but gives a weight of evidence that no chronic effect is to be expected from low concentrations of acetylene.

There is no evidence of irritation following acute exposure, and indeed the use of acetylene as an asphyxiant supports this, thus there is no proposal for a short-term DNEL, nor DNEL for systemic effects.