Registration Dossier
Registration Dossier
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EC number: 200-816-9 | CAS number: 74-86-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limitations with regard to the test method and/or reporting but contributing to a weight of evidence approach
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 925
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details of principles of method given
- GLP compliance:
- no
- Test type:
- other: single exposure of at least 2 hours
- Limit test:
- no
Test material
Test animals
- Species:
- rat
- Strain:
- other: white rat (strain not specified)
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Single strain of white rats of uniform weight used.
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- Duration and method of exposure not reported
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- not reported
- Concentrations:
- Various concentrations, including 78% and 90% acetylene.
- No. of animals per sex per dose:
- Not reported
- Control animals:
- not specified
- Details on study design:
- The anaesthetic potency and toxicity of various concentrations of acetylene was assessed
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- other: respiratory failure
- Effect level:
- 90 other: %
- Remarks on result:
- other: 963,000 mg/m3. Within about 2 hours of the start of exposure (It is assumed this concentration was lethal)
- Dose descriptor:
- other: anaesthesia
- Effect level:
- 78 other: %
- Remarks on result:
- other: 834,600 mg/m3. Induced anaesthesia within 15 minutes of the start of exposure but this was not preceded by a marked excitement stage.
- Mortality:
- Respiratory failure within 2 hours, group size not reported
- Clinical signs:
- other: Not reported
- Body weight:
- Not reported
- Gross pathology:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Inhalation LC50 rats between 78% - 90% acetylene
equivalent to LC50 780,000 - 900,000 ppm - Executive summary:
The inhalation toxicity of acetylene was investigated in rats. 78% induced anaesthesia within 15 minutes and 90% caused respiratory failure within 2 hours.
Inhalation LC50 rats between 78% - 90% acetylene, equivalent to LC50 780,000 - 900,000 ppm (834,600 - 963,000 mg/m3)
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