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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limitations with regard to the test method and/or reporting but contributing to a weight of evidence approach

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1925

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No details of principles of method given
GLP compliance:
no
Test type:
other: single exposure of at least 2 hours
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
No details on test material given

Test animals

Species:
rat
Strain:
other: white rat (strain not specified)
Sex:
not specified
Details on test animals and environmental conditions:
Single strain of white rats of uniform weight used.

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
not specified
Vehicle:
other: air
Details on inhalation exposure:
Duration and method of exposure not reported
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
not reported
Concentrations:
Various concentrations, including 78% and 90% acetylene.
No. of animals per sex per dose:
Not reported
Control animals:
not specified
Details on study design:
The anaesthetic potency and toxicity of various concentrations of acetylene was assessed

Results and discussion

Effect levelsopen allclose all
Dose descriptor:
other: respiratory failure
Effect level:
90 other: %
Remarks on result:
other: 963,000 mg/m3. Within about 2 hours of the start of exposure (It is assumed this concentration was lethal)
Dose descriptor:
other: anaesthesia
Effect level:
78 other: %
Remarks on result:
other: 834,600 mg/m3. Induced anaesthesia within 15 minutes of the start of exposure but this was not preceded by a marked excitement stage.
Mortality:
Respiratory failure within 2 hours, group size not reported
Clinical signs:
Not reported
Body weight:
Not reported
Gross pathology:
Not reported

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Inhalation LC50 rats between 78% - 90% acetylene
equivalent to LC50 780,000 - 900,000 ppm
Executive summary:

The inhalation toxicity of acetylene was investigated in rats. 78% induced anaesthesia within 15 minutes and 90% caused respiratory failure within 2 hours.

Inhalation LC50 rats between 78% - 90% acetylene, equivalent to LC50 780,000 - 900,000 ppm (834,600 - 963,000 mg/m3)