Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 200-816-9 | CAS number: 74-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limitations with regard to the test method and/or reporting but contributing to a weight of evidence approach
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 925
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details of principles of method given
- GLP compliance:
- no
- Test type:
- other: single exposure of at least 2 hours
- Limit test:
- no
Test material
Test animals
- Species:
- rat
- Strain:
- other: white rat (strain not specified)
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Single strain of white rats of uniform weight used.
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- Duration and method of exposure not reported
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- not reported
- Concentrations:
- Various concentrations, including 78% and 90% acetylene.
- No. of animals per sex per dose:
- Not reported
- Control animals:
- not specified
- Details on study design:
- The anaesthetic potency and toxicity of various concentrations of acetylene was assessed
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- other: respiratory failure
- Effect level:
- 90 other: %
- Remarks on result:
- other: 963,000 mg/m3. Within about 2 hours of the start of exposure (It is assumed this concentration was lethal)
- Dose descriptor:
- other: anaesthesia
- Effect level:
- 78 other: %
- Remarks on result:
- other: 834,600 mg/m3. Induced anaesthesia within 15 minutes of the start of exposure but this was not preceded by a marked excitement stage.
- Mortality:
- Respiratory failure within 2 hours, group size not reported
- Clinical signs:
- other: Not reported
- Body weight:
- Not reported
- Gross pathology:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Inhalation LC50 rats between 78% - 90% acetylene
equivalent to LC50 780,000 - 900,000 ppm - Executive summary:
The inhalation toxicity of acetylene was investigated in rats. 78% induced anaesthesia within 15 minutes and 90% caused respiratory failure within 2 hours.
Inhalation LC50 rats between 78% - 90% acetylene, equivalent to LC50 780,000 - 900,000 ppm (834,600 - 963,000 mg/m3)
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