Registration Dossier
Registration Dossier
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EC number: 203-953-2 | CAS number: 112-27-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Toxicology Update: Triethylene glycol.
- Author:
- Ballantyne, B., Snellings, W.M.
- Year:
- 2 007
- Bibliographic source:
- J. Appl. Toxicol. 27, 291 - 299
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Currently no LLNA study is available for assessment. The Guinea Pig Maximization Test (GPMT) has been carried out as an animal test to predict human sensitization for over a decade and is recommended by international test guidelines such as OECD.
Test material
- Reference substance name:
- 2,2'-(ethylenedioxy)diethanol
- EC Number:
- 203-953-2
- EC Name:
- 2,2'-(ethylenedioxy)diethanol
- Cas Number:
- 112-27-6
- Molecular formula:
- C6H14O4
- IUPAC Name:
- 2-[2-(2-hydroxyethoxy)ethoxy]ethan-1-ol
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- unchanged (no vehicle)
Challenge
- Route:
- intradermal and epicutaneous
- Vehicle:
- unchanged (no vehicle)
- Day(s)/duration:
- 24 h
- Details on study design:
- Induction was by intradermal injection of the test substance, followed after 7 days by an epicutaneous application.
After a 14 day rest period epicutaneous challenge doses were applied for 24 h and the site inspected for signs of irritation at 24 and 48 h after removal of the challenge patch.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- no data
- No. with + reactions:
- 0
- Total no. in group:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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