Registration Dossier

Environmental fate & pathways

Biodegradation in water: screening tests

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Readily biodegradable (according to OECD criteria).

Key value for chemical safety assessment

Additional information

The biodegradability of 2,2'-(Ethylenedioxy)diethanol is assessed in a weight-of-evidence approach. For 2,2'-(Ethylenedioxy)diethanol data from a MITI test (OECD 301C) is available (NITE Japan, 1992). Results varied between 25% and 92% degradation after 28 days, which indicates this substance is readily biodegradable.

Additionally, QSAR calculation using OASIS catalogic v5.13.1.156 reveal readily biodegradability of the test substance. In an OECD 301 C (Catalogic 301C v.11.15) 98% degradation was estimated and in an OECD 301B (Catalogic Kinetic 301B v.02.09) 80,9% degradation was estimated.


In conculsion 2,2'-(Ethylenedioxy)diethanol os assessed to be readily biodegradable.

QSAR Disclaimer

In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.


According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.


For the assessment of CAS 112 -27 -6 (Q)SAR results were used for aerobic biodegradability in water. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.