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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
The Excretion and Metabolism of Triethylene Glycol
Author:
Herbert McKennis, Jr., Robert A. Turner, Lennox B. Turnbull, and Edward R. Bowman
Year:
1962
Bibliographic source:
Toxicology and Applied Pharmacology 4, 411-431

Materials and methods

Objective of study:
absorption
distribution
excretion
metabolism
Principles of method if other than guideline:
no information available about testing method
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on exposure:
1 female rabbit was given a single dose of 200 mg/kg TEG via stomach tube. In a similar experiment, another animal received a 2000 mg/kg dose orally for 3 consecutive days. Urine from the dosed animals was subsequently collected for 24 hours (from the animal receiving 200 mg/kg), and during the 3 days of dosing and a subsequent 3-day period (from the animal receiving 2000 mg/kg), respectively.
Duration and frequency of treatment / exposure:
24 hours
Doses / concentrationsopen allclose all
Dose / conc.:
200 mg/kg bw (total dose)
Remarks:
Low dose rabbits
Dose / conc.:
2 000 mg/kg bw (total dose)
Remarks:
High dose rabbits
No. of animals per sex per dose:
2 female rabbits
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

Following the single oral administration of 200 mg/kg, 34.3% of the dose was excreted in the urine as unchanged TEG.

The rabbit dosed with 2000 mg/kg TEG excreted 28.3% of the dose amount in the urine as unchanged TEG, while 35.2% of the administered dose were recovered as a hydroxyacid form of TEG.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: In discussing treatment of TEG poisoning, it was stated that TEG is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. TEG metabolism by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole. In discussing treatment of TEG poisoning, it was stated that TEG is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. TEG metabolism by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole or ethanol.