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EC number: 208-167-3 | CAS number: 513-77-9
Only the average results of the controls and the high dose groups of each species were available.
No-observed-adverse-effect level (NOAEL) for fertility impairmentwas 4,000ppm in rats. These NOAEL values correspond to average doses of 201.5 and 179.5 mg Ba/kg bw/d to male and and female rats, respectively.
A NOAEL on developmental toxicityof 4,000 ppm is also reported. However, the NOAEL is of limited value to evaluate the potential for barium to induce developmental effects. The reason for this limitation is based on the fact that the premating study design did not include exposure of female animals during the gestational period to barium chloride. Therefore, the premating study has to be considered as an inadequate study of developmental toxicity and cannot be used to determine the occurrence of developmental toxicity.
Read across from BaCl2*2H2O to BaCO3:
The toxicity of barium sulfate and barium chloride is based on the concentration of dissolved Ba2 + and therefore on the water solubility of each substance. Barium chloride is known to be well water soluble whereas barium sulfate is low soluble in water. The conclusion is that Ba2+ ions are more bioavailable if BaCl2 is administered as if BaSO4 is administered. Hence, read across to BaSO4 based on worst case consideration andwill likely lead to rather conservative no-effect levels.
Fertility impairment in female rats: NOAEL of 179.5 mg Ba2+/kg bw/d; relates to 258 mg Barium carbonate/kg bw/day (Dietz et al., 1992) Fertility impairment in male rats: NOAEL of 201.5 mg Ba2+/kg bw/d; relates to 290 mg Barium carbonate/kg bw/day (Dietz et al., 1992)
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