Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2008
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only information of a secondary source is available (SIAR 2008).

Data source

Reference
Reference Type:
secondary source
Title:
Barium chloride - Initial assessment profile
Author:
Anonymous
Year:
2008
Bibliographic source:
SIAM 27
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no futher details

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
no data
Doses:
2000 mg/kg bw.
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: secondary literature
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to the SIAR , an acute dermal toxicity study on barium chloride was conducted under OECD TG 402 in compliance with GLP: in this study, the dermal LD50 was greater than 2000 mg/kg bw in rats. However, the primary source for this study is not available: the SIAR refers to a NIER report dated 2008.
Executive summary:

Read-across from soluble to the poorly soluble barium compound is considered acceptable because toxicokinetic data on the poorly soluble barium carbonate indicates a markedly lesser bioavailability than the soluble barium chloride. However, it is to be concluded that this read-across will likely lead to rather conservative no-effect levels.