Registration Dossier
Registration Dossier
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EC number: 208-167-3 | CAS number: 513-77-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2008
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only information of a secondary source is available (SIAR 2008).
- Justification for type of information:
- Read-across from soluble to the poorly soluble barium compound is considered acceptable because toxicokinetic data on the poorly soluble barium carbonate indicates a markedly lesser bioavailability than the soluble barium chloride. However, it is to be concluded that this read-across will likely lead to rather conservative no-effect levels.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Barium chloride - Initial assessment profile
- Author:
- Anonymous
- Year:
- 2 008
- Bibliographic source:
- SIAM 27
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- barium(2+) dichloride dihydrate
- EC Number:
- 600-412-6
- Cas Number:
- 10326-27-9
- Molecular formula:
- BaCl2.2(H2O)
- IUPAC Name:
- barium(2+) dichloride dihydrate
- Test material form:
- solid: crystalline
- Details on test material:
- Test substance: Barium chloride dihydrate
Molecular weight: 208.23 g/mol
Supplier: American Chemical Society
Purity: reagent-grade
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- 2000 mg/kg bw.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: secondary literature
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the SIAR , an acute dermal toxicity study on barium chloride was conducted under OECD TG 402 in compliance with GLP: in this study, the dermal LD50 was greater than 2000 mg/kg bw in rats. However, the primary source for this study is not available: the SIAR refers to a NIER report dated 2008.
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