Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Read-across BaCl2*2H2O to BaCO3:

Based on the negative results in the in-vitro tests for soluble barium compounds (BaCl2*2H2O) and assuming that poorly soluble compounds are less bioavailable, read-across from BaCl2*H2O is performed.


Short description of key information:
in-vitro gene mutation in bacteria (OECD 471): negative
in-vitro gene mutation in mammalian cells (OECD 476): negative
in-vitro chromosome aberration (OECD 473): negative

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

None of the in vitro genotoxicity studies rated as reliable showed any effect in bacterial reverse mutation assays, in mammalian cell gene mutation tests (TK assay) or in mammalian cell chromosome aberration tests, thus the classification criteria according to regulation (EC) 1272/2008 as germ cell mutagen are not met.