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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Very briefly reported without methodological details
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Barium compounds as industrial poisons (an experimental study)
Author:
Tarasenko, N.Y. et al.
Year:
1977
Bibliographic source:
Journal of hygiene, Epidemiology, Microbiology and Immunology 21,4, 361 - 373.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A month's inhalation intoxication of albino rats with barium carbonate dust at a concentration of the aerosol of 33.4 +/- 3.6 mg/m^3 in the chamber yielded data on the character of the action of the substance entering the organism by the respiratory route.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
No further details available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
Albino rats were used.
- Diet: Animals were fed standard diet.
No further information on the test animals was stated.

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: No data
Details on inhalation exposure:
A month's inhalation intoxication of albino rats with barium carbonate dust at a concentration of the aerosol of 33.4 +/- 3.6 mg/m^3 in the chamber yielded data on the character of the action of the substance entering the organism by the respiratory route.
No further information on the inhalation exposure was stated.
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
No data
Duration of treatment / exposure:
1 month
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
33.4 +/- 3.6 mg/m^3
Basis:
analytical conc.
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Positive control:
No data

Examinations

Observations and examinations performed and frequency:
CAGE SIDE OBSERVATIONS: No data

DETAILED CLINICAL OBSERVATIONS: No data

BODY WEIGHT: No data

FOOD CONSUMPTION:
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data

FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data

WATER CONSUMPTION: No data

OPHTHALMOSCOPIC EXAMINATION: No data

HAEMATOLOGY: Yes
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
Red and white blood picture were examined.

CLINICAL CHEMISTRY: Yes
- Animals fasted: No data
Activity of the enzymes were examined.

URINALYSIS: No data

NEUROBEHAVIOURAL EXAMINATION: No data

OTHER: The influence of the test item on the metabolism and vascular tone tonus as well as reduction on the detoxifying function of liver were investigated.
No further information on the observations and examinations performed and frequency were stated.
Sacrifice and pathology:
GROSS PATHOLOGY: Yes, pathomorphological examination of the organs.
HISTOPATHOLOGY: No data
No further information on the sacrifice and pathology were stated.
Other examinations:
No data
Statistics:
No data

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
effects observed, treatment-related
Clinical biochemistry findings:
effects observed, treatment-related
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
effects observed, treatment-related
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
HAEMATOLOGY
The examination revealed changes in the red and white blood picture.

CLINICAL CHEMISTRY
The examination revealed inhibition of the activity of enzymes.

GROSS PATHOLOGY
Pathomorphological examination of the organs showed the picture of desquamative bronchitis in the bronchi and focal thickenings of the interalveolar septa in the lung tissue. Sings of granular dystrophy developed in the heart, liver and kidneys.

OTHER FINDINGS: The examination revealed influence of the test item on the metabolism and vascular tonus as well as reduction in the detoxifying function of the liver.

Effect levels

Dose descriptor:
other: not applicable
Effect level:
other: not applicable
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: see 'Remark'

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
There were changes noted in red and white blood cells, inhibition of enzyme activity, effects on the metabolism and vascular tone, and reduced hepatic activity. The report did not define any of the changes.
Pathomorphological examination revealed a picture of desquamative bronchitis in the bronchi and focal thickening of the interalveolar septa in lung tissue. There were signs of granular dystrophy in the heart, liver, and kidney.