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EC number: 208-167-3 | CAS number: 513-77-9
Toxicological information
Repeated dose toxicity: inhalation
Currently viewing:
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Very briefly reported without methodological details
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Barium compounds as industrial poisons (an experimental study)
- Author:
- Tarasenko, N.Y. et al.
- Year:
- 1 977
- Bibliographic source:
- Journal of hygiene, Epidemiology, Microbiology and Immunology 21,4, 361 - 373.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A month's inhalation intoxication of albino rats with barium carbonate dust at a concentration of the aerosol of 33.4 +/- 3.6 mg/m^3 in the chamber yielded data on the character of the action of the substance entering the organism by the respiratory route.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Barium carbonate
- EC Number:
- 208-167-3
- EC Name:
- Barium carbonate
- Cas Number:
- 513-77-9
- Molecular formula:
- BaCO3
- IUPAC Name:
- barium carbonate
- Test material form:
- solid
- Details on test material:
- No further details available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Albino rats were used.
- Diet: Animals were fed standard diet.
No further information on the test animals was stated.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: No data
- Details on inhalation exposure:
- A month's inhalation intoxication of albino rats with barium carbonate dust at a concentration of the aerosol of 33.4 +/- 3.6 mg/m^3 in the chamber yielded data on the character of the action of the substance entering the organism by the respiratory route.
No further information on the inhalation exposure was stated. - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data
- Duration of treatment / exposure:
- 1 month
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
33.4 +/- 3.6 mg/m^3
Basis:
analytical conc.
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Positive control:
- No data
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: No data
BODY WEIGHT: No data
FOOD CONSUMPTION:
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data
WATER CONSUMPTION: No data
OPHTHALMOSCOPIC EXAMINATION: No data
HAEMATOLOGY: Yes
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
Red and white blood picture were examined.
CLINICAL CHEMISTRY: Yes
- Animals fasted: No data
Activity of the enzymes were examined.
URINALYSIS: No data
NEUROBEHAVIOURAL EXAMINATION: No data
OTHER: The influence of the test item on the metabolism and vascular tone tonus as well as reduction on the detoxifying function of liver were investigated.
No further information on the observations and examinations performed and frequency were stated. - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes, pathomorphological examination of the organs.
HISTOPATHOLOGY: No data
No further information on the sacrifice and pathology were stated. - Other examinations:
- No data
- Statistics:
- No data
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- effects observed, treatment-related
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- HAEMATOLOGY
The examination revealed changes in the red and white blood picture.
CLINICAL CHEMISTRY
The examination revealed inhibition of the activity of enzymes.
GROSS PATHOLOGY
Pathomorphological examination of the organs showed the picture of desquamative bronchitis in the bronchi and focal thickenings of the interalveolar septa in the lung tissue. Sings of granular dystrophy developed in the heart, liver and kidneys.
OTHER FINDINGS: The examination revealed influence of the test item on the metabolism and vascular tonus as well as reduction in the detoxifying function of the liver.
Effect levels
- Dose descriptor:
- other: not applicable
- Effect level:
- other: not applicable
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: see 'Remark'
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- There were changes noted in red and white blood cells, inhibition of enzyme activity, effects on the metabolism and vascular tone, and reduced hepatic activity. The report did not define any of the changes.
Pathomorphological examination revealed a picture of desquamative bronchitis in the bronchi and focal thickening of the interalveolar septa in lung tissue. There were signs of granular dystrophy in the heart, liver, and kidney.
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