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Ecotoxicological information

Endpoint summary

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Description of key information

Short term toxicity to fish

A reliable 96 h LC50 value of 160 mg/L (as active acid) has been determined for the effects of ATMP-H on mortality of Salmo gairdneri (now known as Oncorhynchus mykiss).

A 96 h LC50 value of >400-500 mg/L has been determined for the effects of ATMP-5Na salt on the mortality of the marine fish Cyprinodon variegatus. This corresponds to a 96 h LC50 value of >282 mg/L (as active ATMP acid) based on the active acid content (28.2%) reported in the test report. The study was conducted with ATMP-5Na (CAS 2235-43-0). The result is expressed in terms of active acid and therefore no adjustment to the EC50 value was necessary for read-across.

Long term toxicity to fish

A 60-day NOEC value of 23 mg/L (as active acid) has been determined for the effects of ATMP-H on growth of the fish O. mykiss. This study represents the only value available for this endpoint.

Short term toxicity to invertebrates

A 48 h LC50 value of 94 mg/L (as active acid) has been determined for the effects of ATMP-H on mortality of the marine invertebrate Acartia tonsa. This study represents the lowest reliable value available for this endpoint.

A 48 h EC50 value of 297 mg/L (as active acid) has been determined for the effects of ATMP-H on the immobility of the freshwater flea Daphnia magna.

Long term toxicity to invertebrates

A 28 day NOEC value of ≥ 25 mg/L (as active acid) has been determined for the effects of ATMP-H on adult survival and reproduction of D. magna. The study represents the lowest reliable value available for this endpoint.

A 96 h NOEC value of 96 mg active acid/L has also been determined for the effects of ATMP-H on the growth of the eastern oyster Crassostrea virginica.

Toxicity to algae and cyanobacteria

The endpoint has been waived because it is not possible to ascertain the true toxicity of ATMP towards algae.

In accordance with Section 2 of REACH Annex XI, the study does not need to be conducted because an assessment of the toxicity to aquatic algae and cyanobacteria is technically not possible due to the substance's complexing properties of essential nutrients present in the test media.

Additional information

Read-across between ATMP salts and the parent acid substance is considered appropriate because:

The category hypothesis is that all the members are various ionised forms of the acid CAS 6419-19-8. The main assumption is that sodium and potassium are not significant in respect of all the properties under consideration. ATMP salts will dissociate into ATMP and the counter-ion when in contact with aqueous and moist media, therefore the two substances should be assessed separately. In dilute aqueous conditions of defined pH a salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present and will be fully dissociated. Hence some properties for a salt can be directly read-across (with suitable mass correction) to the parent acid and vice versa. The ammonium salt does present a particular issue since ammonia drives the toxicity of the substance. The toxicity of the ammonium salt is discussed further in the CSR.