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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report Date:
1983

Materials and methods

Principles of method if other than guideline:
Application of radiolabelled substance and observation of absorption and excretion in urine.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
The substance used was a neutralised solution of ATMP.
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Vehicle:
water
Duration of exposure:
24 h
Doses:
200 µl of a 1% aqueous solution was applied to 10 cm² area of shaved skin.
No. of animals per group:
2 male, 2 female

Results and discussion

Any other information on results incl. tables

absorption: 0.603% (male); 0.94% (female)

excretion: the majority of the absorbed radiolabelled ATMP was excreted in the urine within 24 hours of treatment.

Applicant's summary and conclusion

Conclusions:
A neutralised solution of ATMP was tested for dermal absorption. It was concluded that absorption was very low (<1%) and that most of the absorbed substance was excreted in the urine.