Registration Dossier

Administrative data

Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2010-09-01
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The activity of the Laboratory Department is certified according to the ISO 9001:2008 standard.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
One liter of demineralised water has been adjusted to pH = 1.5 by adding HCl 37%; 300 ml of the previous solution has been spilled in one glass beaker and the temperature has been regulated at 37°C. Agitating sufficient quantity of the Ba-substance has been dissolved to reach a saturated solution keeping the temperature at 37 °C. After 15 minutes additional reaction time the solution has been filtered with preheated filtering equipment. The barium content in the filtrate has been determined by gravimetric analysis (the filtrate had for BaCl2*2H2O test a pH = 0.6).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): Barium chloride cristalli
-Chemical name: Barium chloride dihydrate
- Molecular formula: BaCl2 *2H2O
- Molecular weight: 244.26 g/mol
- Physical state: Solid, white powder
- Storage condition of test material: Ambient temperature, dark, dry and original containers
No further information on the test material was stated.

Results and discussion

pH value
pH value:
0.8
Temp.:
37 °C
Concentration:
510.4 g/L
Remarks on result:
other: HCl media pH 1.5

Applicant's summary and conclusion

Conclusions:
510.4 g/L barium chloride dissolves in a artificial gastic fluid of HCl solution (pH 1.5) at 37°C. After dissolution the pH value of the solution was: 0.8