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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Publication not available

Data source

Reference
Reference Type:
publication
Title:
A biological implication of DMSO based on a review of its chemical properties
Author:
Rammler DH and Zaffaroni
Year:
1967
Bibliographic source:
Ann NY Acad. Sci. 141, 13-23

Materials and methods

Type of study / information:
Type of experience: Human
Endpoint addressed:
basic toxicokinetics

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
In man, DMSO is oxidized into dimethylsulfone DMSO2, metabolite excreted by urine (17-22 %).
DMSO is reduced into dimethylsulfide, DMS, a volatile metabolite, responsible for garlic odour of exhaled air (1 %).
About 85 % is excreted unchanged, both by urine (50 %) and feces (50 %).
The half time for elimination in volunteers given 1000 mg/kg intravenously is 4 days.
By oral route, the same dose is excreted about 51 % as DMSO and about 10 % DMSO2 in urine within 120 hrs.

Applicant's summary and conclusion