Registration Dossier

Administrative data

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Reliability:
2 (reliable with restrictions)
Data waiving:
other justification
Justification for data waiving:
other:

Data source

Reference
Reference Type:
publication
Title:
The acute oral toxicity, repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds
Author:
Schafer EW Jr, Bowles WA Jr and Hurlbut J
Year:
1983
Bibliographic source:
Arch. Environm. Contam. Toxicol., 12, 355-382

Materials and methods

Test guideline
Guideline:
other:
Principles of method if other than guideline:
Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol, according to methods described by DeCino et al. (1966), Schafer (1972), and Schafer et al. (1967). Other oral dosing methods were occasionally used (pellets, gelatin capsules) (Schafer, 1972). LD values were calculated by the method of Thompson (1948), Thompson and Weil (1952), and Weil (1952). Repellency tests were conducted by the methods of Starr et al. (1964) and Schafer and Brunton (1971), and R50's (analogous to LD50 s) were calculated either by the method of Litchfield and Wilcoxin (1949) or Thompson and Weil (1952).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test organisms

Test organisms (species):
other: other avian

Study design

Details on test conditions:
Method: wild-trapped birds were preconditionned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol, according to methods described by DeCino et al (1966), Schafer (1972) and Schafer et al (1967).

LD50 values were calculated by the method of Thompson (1948), Thompson and Weil (1952) and Weil (1952).
Repellency tests were conducted by the methods of Starr et al. (1964) and Schafer and Brunton (1971), and R50's were calculated either by the method of Litchfield and Wilconxin
(1949) or Thompson and weil (1952).

Bird species: Agelaius phoeniceus (Red-winged blackbird).

Results and discussion

Effect levels
Duration (if not bolus):
18 h
Dose descriptor:
LD50
Effect level:
100 mg/kg bw
Basis for effect:
mortality

Applicant's summary and conclusion