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EC number: 247-148-4 | CAS number: 25637-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported. Test material was received 12 July 1977, study report was finalised 7 December 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Five male and 5 female rats of the Charles River CD strain (obtained from Charles River Laboratories, Portage, Michigan) weighing from 200 to 211 grams, were used for this study. The rats were housed by sex in groups of 5 rats per cage, in hanging wire-mesh cages in temperature and humidity controlled quarters. They were maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.I.H.) entitled "Guide for the Care and Use of Laboratory Animals". Water and Purina Laboratory Chow were available ad libitum, except for an overnight period preceding oral administration during which food, but not water was withheld.
The test material was suspended in corn oil and administered orally by gavage at a dosage level of 10,000 mg/kg. A volume of 20 ml/kg of body weight was administered. All rats were observed for mortality and pharmacotoxic signs during the first four hours after dosing, at 24 hours and daily thereafter for a total of 14 days. Body weights were recorded initially and at 7 and 14 days. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hexabromocyclododecane
- EC Number:
- 247-148-4
- EC Name:
- Hexabromocyclododecane
- Cas Number:
- 25637-99-4
- Molecular formula:
- C12H18Br6
- IUPAC Name:
- (1S,2S,5S,6S,9S,10S)-1,2,5,6,9,10-hexabromocyclododecane
- Details on test material:
- Test material identified as 'Firemaster 100 Lot 53 77.902' and was received as a fine white powder.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
Charles River Laboratories, Portage, Michigan.
- Age at study initiation:
Not reported.
- Weight at study initiation:
200-211 grams.
- Fasting period before study:
Yes, overnight.
- Housing:
The rats were housed by sex in groups of 5 rats per cage, in hanging wire-mesh cages in temperature and humidity controlled quarters.
- Diet (e.g. ad libitum):
ad libitum, except for fasting period.
- Water (e.g. ad libitum):
ad libitum
- Acclimation period:
Not reported.
ENVIRONMENTAL CONDITIONS
Animals were maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.I.H.) entitled "Guide for the Care and Use of Laboratory Animals".
IN-LIFE DATES: From: Day 1 To: Day 14
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle:
Not reported.
- Amount of vehicle (if gavage):
20 ml/kg bw
- Justification for choice of vehicle:
Not reported.
- Lot/batch no. (if required):
Not reported.
- Purity:
Not reported.
MAXIMUM DOSE VOLUME APPLIED:
20 ml/kg bw
DOSAGE PREPARATION (if unusual):
The test material was suspended in corn oil and administered orally by gavage at a dosage level of 10,000 mg/kg. - Doses:
- 10,000 mg/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration:
14 days
- Frequency of observations and weighing:
Daily
- Necropsy of survivors performed:
no
- Other examinations performed:
All rats were observed for mortality and pharmacotoxic signs during the first four hours after dosing, at 24 hours and daily thereafter for a total of 14 days. - Statistics:
- Not reported.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- > 10 000 mg/kg bw
- Remarks on result:
- other: 95% CL not applicable
- Mortality:
- None of the 10 rats died during the 14-day observation period. The minimum lethal dose was found to be greater than 10,000 mg/kg.
- Clinical signs:
- other: The following pharmacotoxic signs were observed during the 14-day observation period: Males: Normal Hypoactivity Corneal Ptosis Opacity 1 hour 5/5 - - - 2½ hours 2/5 3/5 - - Days 1-5 5/5
- Gross pathology:
- Not conducted.
- Other findings:
- Not reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The minimum lethal dose by the oral route of administration was found to be greater than 10,000 mg/kg.
- Executive summary:
Five male and 5 female rats of the Charles River CD strain weighing from 200 to 211 grams, were used for this study. The test material was suspended in corn oil and administered orally by gavage at a dosage level of 10,000 mg/kg. A volume of 20 ml/kg of body weight was administered. All rats were observed for mortality and pharmacotoxic signs during the first four hours after dosing, at 24 hours and daily thereafter for a total of 14 days. None of the 10 rats died during the 14-day observation period. The minimum lethal dose was found to be greater than 10,000 mg/kg.
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