Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-148-4
CAS number: 25637-99-4
The following available information was available for the irritation/corrosion endpoint:Skin irritation/corrosion:Dean, W. P. and Leong, B. K. J. (1977). Acute toxicity study in Rabbits and Rats. Report no.: 163-499. Report date: 1977-12-07.Eye irritation/corrosion:Dean, W. P. and Leong, B. K. J. (1977). Acute toxicity study in Rabbits and Rats. Report no.: 163-499. Report date: 1977-12-07.Dean and Leong (1977) was selected as the key study for both exposure routes based upon the depth of reporting of the methodologies and results and the reliability score of 2 (according to the criteria of Klimisch et al, 1997). Additional information is available, however this information is included as supporting information only as the reliability assessment and depth of reporting indicate the the additional studies are less reliable that the key study.
Dean and Leong (1977) was selected
as the key study for both exposure routes. Testing of the different
exposure routes was carried out with separate test animals and with
different test methodologies.
In the key study the test
substance was applied to 6 rabbits with intact (3 animals) and abraded
skin (3 animals). The test substance was removed after 4 hours and the
sites washed with tepid water. Skin irritation was assessed 1, 24, 48
and 72 hours following removal of the test substance.
The reported results for animals with intact skin were, erythema 0.33
mean (0.5 maximum) at 24 hours and 0.16 mean (0.5 maximum) at 48 hours,
all erythema was fully reversed at the 72 hour observation period. No
edema was reported at any observation period during the study. These
results were supported by Lewis and Palanker (1978) and Monma et al. (1984)
which all reported primary dermal irritation index scores of 0 at the 72
hour observation period.
the key study, the test substance was placed into the cupped
conjunctival sac of the right eye of 3 rabbits following which the
eyelids were gently held together for one second. The left eye served as
the untreated control for each rabbit. None of the rabbits received a
wash out. The treated eyes were examined for irritation 24, 48, 72 hours
and 7 days following application of the test substance. The results of
the key study are:
These results are supported by
Crown (1984), who reported results of <0.5 mean (1 max) for all effects
and recorded a complete reversion of effects at the 73 hour observation
time, and Lewis and Palanker (1978) who reported maximum results of 2
for conjuctivae redness and chemosis at 24 hours and 1 for conjuctivae
redness and chemosis and discharge at 48 hours; all results were fully
reversed at the 4 day observation time.
HBCDD is not a skin or eye irritant and does not meet the criteria for
classification according to 67/548/EEC and EC Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again