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EC number: 247-148-4
CAS number: 25637-99-4
The key study for each route of exposure was chosen for this endpoint as follows:Oral exposure route:Dean, W. P. and Leong, B. K. J. (1977a). Acute toxicity study in Rabbits and Rats.Report no.: 163-499. Report date: 1977-12-07.Dermal exposure route:Dean, W. P. and Leong, B. K. J. (1977a). Acute toxicity study in Rabbits and Rats. Report no.: 163-499.Report date: 1977-12-07.Inhalation route:Dean, W. P. and Leong, B. K. J. (1977a). Acute toxicity study in Rabbits and Rats. Report no.: 163-499. Report date: 1977-12-07.Dean and Long (1977a) was chosen as the key study for each route of exposure based upon the result of the reliability assessment, age of the study and depth of reporting. This study was awarded a reliability score of 2 according to the Klimisch et al. (1997) criteria. Although other sources of available information were also awarded a reliability score of 2 according to the same criteria, it was considered that this study provided more complete reporting of test methodology and results and so was chosen as the key study.
Key information for chemical safety assessment:
Acute toxicity: oral
Acute toxicity: dermal
Descriminating dose >20,000 mg/kg bw (male/female)
Acute toxicity: inhalation
Descriminating concentration (4 hours) >202.14 mg/l air (nominal)
Dean and Long (1977) was selected as the key study for each exposure
route as stated above. The results of the key studies were supported by
other additional non-key studies as follows:
All available information reported a lack of mortality and systemic
toxicity for the oral route. A short summary of results is provided
Lewis and Palanker (1978) supported the key study and found no mortality
or signs of systemic toxicity after exposure to the substance by the
dermal route. Lewis and Palanker reported an LD50 of >8 g/kg
(male/female) based upon an absence of mortality at the highest dose
level tested. The key study (Dean and Long, 1977) confirms this result
with the reported LD50 of >20,000 mg/kg bw (male/female).
As for dermal toxicity Lewis and Palanker (1978) is provided in support
of the key study. Lewis and Palanker (1978) reported an LC50 value of
>200 mg/l air (nominal) (male/female). This value supported the key
study (Dean and Long, 1977) which reported a result of 202.14 mg/l air
Multiple studies have demonstrated that HBCDD is not acutely toxic by
the oral, dermal and inhalation routes. Thus HBCDD does not meet the
criteria for classification as acutely toxic according to Directive
67/548/EEC and EC Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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