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EC number: 247-148-4
CAS number: 25637-99-4
The following information is available for this endpoint:Graves, W. C. and Swigert, J. P (1997). Hexabromocyclododecane (HBCD): 48-hour flow-through acute toxicity test with the Cladoceran (Daphnia magna). Report no.: 439A-102. Report date: 1997-05-21.Priestly, S. L. (2008a). EPS - Styropor F 215-N, Lot 39-2704: Acute toxicity to Daphnia magna. Report no.: 2631/0001.Report date: 2008-10-27.Priestly, S. L. (2008b). XPS - Styrodur 2800C 40mm, Lot 286 985 75LO: Acute Toxicity to Daphnia magna. Report no.: 2631/0003. Report date: 2008-10-27.Graves and Swigert (1997) was selected as the key study as it was considered to be the most reliable and relevant study available.
The commercial HBCDD product was
not acutely toxic to Daphnia magna. HBCDD’s 48 hour EC50, no
mortality/immobility concentration, and NOEC (6.8 µg/L nominal) in Daphnia
magna were all greater than gamma HBCDD’s water solubility (3.4 µg/L
measured). The highest nominal dose tested was twice gamma HBCDD’s water
solubility. Nominal test concentrations were 0, 1.5, 2.2, 3.2, 4.6 and
6.8 µg/L which corresponded to mean measured concentrations (HPLC with
UV/VIS detector) of 0, 2.4, 1.8, 2.1, 2.3 and 3.2 µg/L, respectively
(Graves and Swigert, 1997). A composite of three manufacturers'
commercial products was used as test article in the above study. The
dose levels in the study were based on the water solubility of HBCDD
(approxiamtely 3.4 µg/L) determined via quantiation on the gamma
diastereomer. The alpha and beta diastereomers were not quantifiable at
a gamma concentration of 3.4 µg/L due to their low concentrations in the
test article. Correcting for gamma diasteromer content in the test
article, the 48 hour NOEC was > 8.5 µg/L of the commercial product in
The lack of acute toxicity in
daphnia was also observed in the Daphnia 21 day study, using the
commercial HBCDD product as test article. No mortality was observed at
48 hour at nominal concentrations up to 13.6 µg/L (11 µg/L, measured,
based on gamma diasteromer). Correcting for the content of the gamma
diastereomer, the nominal concentration was 17.2 µg/L. Thus, the 48 hour
EC50 in daphnia of the HBCDD commercial product is > 17.2 ug/L.
The HBCDD commercial product has
not been tested in Daphnia at higher doses.
The 48 hour effective loading
rate 50 (EL50) of XPS or EPS foam boards flame retarded with HBCDD was >
100 mg board/L.
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