Registration Dossier
Registration Dossier
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EC number: 202-981-2 | CAS number: 101-84-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient data on a non-GLP study. However data are consistent with low toxicity observed via oral route and low degree of dermal penetration.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diphenyl ether
- EC Number:
- 202-981-2
- EC Name:
- Diphenyl ether
- Cas Number:
- 101-84-8
- Molecular formula:
- C12H10O
- IUPAC Name:
- phenoxybenzene
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 3160, 5010 or 7940 mg/kg
- No. of animals per sex per dose:
- 1-2/sex/dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died
- Clinical signs:
- other: Signs of Intoxication: Reduced appetite and activity (3 -5 days)
- Gross pathology:
Survivors (14 days): Viscera appeared normal
Any other information on results incl. tables
Mortality: 0/1 male at 3160 mg/kg, 0/1 female at 5010 mg/kg and 0/1 male and 0/1 female at 7940 mg/kg
Signs of Intoxication: Reduced appetite and activity (3 -5 days)
Survivors (14 days): Viscera appeared normal
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: United Nations GHS
- Conclusions:
- The acute dermal toxicity in rabbits is >7940 mg/kg.
- Executive summary:
Undiluted Diphenyl Oxide was dermally applied to Sprague-Dawley albino rats at dose levels of 3160, 5010 or 7940 mg/kg. The acute dermal toxicity in rabbits was determined to be >7940 mg/kg.
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