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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient data on a non-GLP study. However data are consistent with low toxicity observed via oral route and low degree of dermal penetration.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: No data
Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diphenyl ether
EC Number:
202-981-2
EC Name:
Diphenyl ether
Cas Number:
101-84-8
Molecular formula:
C12H10O
IUPAC Name:
phenoxybenzene
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
3160, 5010 or 7940 mg/kg
No. of animals per sex per dose:
1-2/sex/dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Based on:
test mat.
Mortality:
No animals died
Clinical signs:
other: Signs of Intoxication: Reduced appetite and activity (3 -5 days)
Gross pathology:

Survivors (14 days): Viscera appeared normal

Any other information on results incl. tables

Mortality: 0/1 male at 3160 mg/kg, 0/1 female at 5010 mg/kg and 0/1 male and 0/1 female at 7940 mg/kg

Signs of Intoxication: Reduced appetite and activity (3 -5 days)

Survivors (14 days): Viscera appeared normal

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: United Nations GHS
Conclusions:
The acute dermal toxicity in rabbits is >7940 mg/kg.
Executive summary:

Undiluted Diphenyl Oxide was dermally applied to Sprague-Dawley albino rats at dose levels of 3160, 5010 or 7940 mg/kg. The acute dermal toxicity in rabbits was determined to be >7940 mg/kg.