Registration Dossier
Registration Dossier
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EC number: 202-981-2 | CAS number: 101-84-8
Endpoint summary
Administrative data
Description of key information
Additional information
Three short term toxicity tests to freshwater fishes were available. One study was identified as the key study and reported a 96-hr LC50 value for rainbow trout (Oncorynchus mykiss) of 4.2 mg/L Diphenyl Oxide (DPO or Diphenyl Ether). Two laboratory studies and a quantitative structure-activity relationship (QSAR) model estimation were available for short term toxicity to aquatic invertebrate Daphina magna. A key study reported 48 -hr EC50 value of 1.96 mg/L DPO. Two laboratory studies and a QSAR model estimation were available for short term toxicity to aquatic plant green algae
Psuedokirchnerilla subcapitata (formerly known as Selenastrum capricornutum). A key study reported 72 - hr ErC50 (growth rate) of 0.58 mg/L and EbC50 (biomass) of 0.405 mg/L using initial measured concentration. The results were recalculated using arithmetic mean measured concentration between initial and 72 hour measurement and the values were 72 - hr ErC50 (growth rate) of 0.455 mg/L and EbC50 (biomass) of 0.304 mg/L.
An additional study examined the possible genotoxic and teratogenic effects of DPO on two species of sea urchings (Paracentrotus lividus and Sphearechinus granularis). Also, the potential effect of diphenyl ether on activated sludge microorganisms maintained in an aerobic environment resulted in an EC50 of >100 mg/l (highest concentration tested).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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