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Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
LD50 study in female rats, 5 rats/dose level.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diphenyl ether
EC Number:
202-981-2
EC Name:
Diphenyl ether
Cas Number:
101-84-8
Molecular formula:
C12H10O
IUPAC Name:
phenoxybenzene
Details on test material:
Industrial Grade Diphenyl Oxide
Reference No.: XA-1075-L
Appearance: light yellow liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
single-dose intubation using calibrated syringe and suitable rubber catheter
Doses:
1.58, 2.0, 2.52, 3.16 or 3.98 g/kg
No. of animals per sex per dose:
5 female rats/dose
Control animals:
no
Details on study design:
Animals subjected to acute oral toxicity studies were fed by single-dose intubation using a calibrated syringe and a suitable rubber catheter. Animals were fasted overnight prior to dosing. Material was administered undiluted. All animals were weighed and observed at intervals over a two-week post-feeding period or until any weight loss is regained and the animals appear healthy. Pathological observation is made on representative animals.
Statistics:
No data

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
2.83 other: g/kg
95% CL:
2.49 - 3.21
Mortality:
Mortality: 0/5 for 1.58 g/kg, 0/5 for 2.0 g/kg, 1/5 for 2.52 g/kg, 4/5 for 3.16 g/kg and 5/5 for 3.98 g/kg
Clinical signs:
other: 1st day- Starting at 2.52 g/kg and up, the rats looked sleepy and depressed; 3rd day- rats given 2.52 g/kg had urine soaked hind quarters and rats given 3.16 g/kg were urine soaked and had red nasal discharge
Gross pathology:
No data
Other findings:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: United Nations GHS
Conclusions:
The acute oral lethality of the test material is low. The acute oral LD50 in female rats was calculated to be 2830 mg/kg body weight (95% confidence limits 2490-3210 mg/kg).
Executive summary:

A sample of industrial grade diphenyl oxide XA-1075-L, was submitted to Chemical Biology Research for evaluation of acute oral lethality, eye and skin irritation properties, and for definition of industrial handling hazards involving acute exposures. The test material is in the early stages of application development. The objective of this study was to provide initial toxicological information on the industrial grade material. As applications are developed, additional appropriate toxicological tests may be required.

The acute oral lethality of the test material is low. The acute oral LD50 in .female rats was calculated to be 2.83 g/kg body weight (95% Confidence Limits 2.49-3.21 g/kg).* There is little likelihood that internal. injury would result from acute ingestion of amounts of the material one might encounter incidental to industrial handling.

Eye contact with the test material would likely result in very slight pain, very slight transient conjunctival inflammation, and possibly a slight transient corneal injury. Safety glasses are recommended whenever the likelihood of eye contact exists.

Prolonged skin contact with the test material would likely result in slight redness and moderate swelling. However, if contact is repeated and/or contaminated clothing is worn for several days moderate redness, moderate swelling and a moderate chemical burn may result. The test material is not likely to be absorbed

through the skin in acutely toxic amounts. Prolonged and/or repeated skin contact should be avoided. If contact occurs, the skin should be decontaminated with soap and water and contaminated clothing thoroughly cleaned before re-use.