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Registration Dossier
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EC number: 203-529-7 | CAS number: 107-88-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1949
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 949
- Report date:
- 1949
- Reference Type:
- publication
- Title:
- Unnamed
- Report date:
- 1949
Materials and methods
- Principles of method if other than guideline:
- acute skin irritation test
- GLP compliance:
- no
Test material
- Reference substance name:
- Butane-1,3-diol
- EC Number:
- 203-529-7
- EC Name:
- Butane-1,3-diol
- Cas Number:
- 107-88-0
- Molecular formula:
- C4H10O2
- IUPAC Name:
- butane-1,3-diol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 1,3-Butylenglykol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: shaved or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 2 h
- Details on study design:
- The rats were exposed to the test substance for 2 h at the shaved or abraded abdominal skin
Results and discussion
In vivo
Results
- Irritation parameter:
- other: overall evaluation
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of irritation were observed
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the conditions of this study, the test substance was not irritating to the skin.
- Executive summary:
Rats were exposed for 2 h to neat test substance at the abdominal intact or abraded abdominal skin. No signs of irritation were oberved (Fischer et al.,1949; Loeser, 1949).
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