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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1949
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1949
Report date:
1949
Reference Type:
publication
Title:
Unnamed
Report date:
1949

Materials and methods

Principles of method if other than guideline:
acute skin irritation test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butane-1,3-diol
EC Number:
203-529-7
EC Name:
Butane-1,3-diol
Cas Number:
107-88-0
Molecular formula:
C4H10O2
IUPAC Name:
butane-1,3-diol
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 1,3-Butylenglykol

Test animals

Species:
rat
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
other: shaved or abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
2 h
Details on study design:
The rats were exposed to the test substance for 2 h at the shaved or abraded abdominal skin

Results and discussion

In vivo

Results
Irritation parameter:
other: overall evaluation
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No signs of irritation were observed

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Under the conditions of this study, the test substance was not irritating to the skin.
Executive summary:

Rats were exposed for 2 h to neat test substance at the abdominal intact or abraded abdominal skin. No signs of irritation were oberved (Fischer et al.,1949; Loeser, 1949).