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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1951
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study with sufficient details reported in former publications, but purity of the substance not stated and some study details are lacking.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1951
Report date:
1951
Reference Type:
publication
Title:
Unnamed
Year:
1948
Report date:
1948
Reference Type:
publication
Title:
Unnamed
Year:
1944
Report date:
1944

Materials and methods

Principles of method if other than guideline:
acute inhalation toxicity test, similar to the inhalation hazard test described in OECD guideline 403.
GLP compliance:
no
Test type:
other: inhalation hazard test
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butane-1,3-diol
EC Number:
203-529-7
EC Name:
Butane-1,3-diol
Cas Number:
107-88-0
Molecular formula:
C4H10O2
IUPAC Name:
butane-1,3-diol
Test material form:
liquid
Details on test material:
Name of test material (as cited in study report): 1,3-butanediol

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
exposure to saturated vapour
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 8 h
Concentrations:
saturated vapour, concentration not stated in the publication; a concentration of about 78 ppm (292 mg/m3) can be estimated based on a vapour pressure of 0.08 hPa at 20 °C.
No. of animals per sex per dose:
6 males
Control animals:
not specified
Details on study design:
The animals were exposed for up to 8 h (geometric time series with a factor of 2) to a stream of air, saturated with vapours of the test substance. The saturation was performed by passing the air through a fritted disc bubbler at room temperature. The duration of observation period following administration was 14 days.

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
78 ppm
Based on:
other: saturated vapour
Exp. duration:
8 h
Remarks on result:
not determinable due to absence of adverse toxic effects
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
292 mg/m³ air
Based on:
other: saturated vapour
Remarks:
calculated based on a vapour pressure of 0.08 hPa at 20 °C
Exp. duration:
8 h
Remarks on result:
not determinable due to absence of adverse toxic effects

Any other information on results incl. tables

No deaths occurred.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
A single 8 h exposure to saturated vapour (concentration not stated, about 78 ppm or 292 mg/m3) produced no mortality in male rats.
Executive summary:

No lethal effects were observed in male rats after a single 8 h of exposure to saturated vapour (concentration not stated, about 78 ppm or 292 mg/m3) (Smyth et al., 1951).