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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1949
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1949
Report date:
1949

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
acute and repeated dermal irritation test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butane-1,3-diol
EC Number:
203-529-7
EC Name:
Butane-1,3-diol
Cas Number:
107-88-0
Molecular formula:
C4H10O2
IUPAC Name:
butane-1,3-diol
Test material form:
liquid
Details on test material:
Name of test material (as cited in study report): 1,3-Butylenglykol, purity not stated

Method

Type of population:
general
Route of exposure:
dermal
Reason of exposure:
intentional
Details on exposure:
Volunteers were exposed to neat substance either at the intact upper arm and fore arm skin (single exposure: dose, occlusion and duration not stated, repeated exposure: 16 days, every other day, 5 g on 9 cm2, occluded for 24 h) or at the oral mucosa (dose and duration not stated).

Results and discussion

Results of examinations:
No signs of irritation were oberved at the skin or mouth mucosa in these test protocols.

Applicant's summary and conclusion

Conclusions:
Under the conditions of this study, the test substance was not irritating to skin or mouth mucosa.
Executive summary:

Volunteers were exposed to neat test substance either at the intact upper arm and fore arm skin (single exposure: dose, occlusion and duration not stated, repeated exposure: 16 days, every other day, 5 g on 9 cm2, occluded for 24 h) or at the oral mucosa (dose and duration not stated). No signs of irritation were observed (Fischer et al., 1949; Loeser, 1949).