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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Study period:
2008
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary source: NLM ChemID data base cites Raw's Handbook (not available)

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Principles of method if other than guideline:
acute dermal toxicity test
GLP compliance:
not specified
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Butane-1,3-diol
EC Number:
203-529-7
EC Name:
Butane-1,3-diol
Cas Number:
107-88-0
Molecular formula:
C4H10O2
IUPAC Name:
butane-1,3-diol
Test material form:
liquid

Test animals

Species:
rabbit

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 20 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute dermal toxicity in rabbits was low (LD50 > 20000 mg/kg bw).
Executive summary:

The dermal LD50 in rabbits is > 20000 mg/kg (ChemID, 2008).