Registration Dossier
Registration Dossier
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EC number: 202-423-8 | CAS number: 95-48-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only one dose, individual animal data not shown, exposure period: 1 hour
Data source
Reference
- Reference Type:
- publication
- Title:
- Bio-Fax data sheet: o-cresol
- Author:
- Industrial Bio-Test Laboratories Inc.
- Year:
- 1 969
- Bibliographic source:
- Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA
Materials and methods
- Principles of method if other than guideline:
- Method: room temperature, total air flow: 10.0 lpm (no further information) observation for clinical signs and mortality, gross autopsy.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
- Details on test material:
- IUCLID4 Test substance: other TS: o-cresol, no data on purity, MP 30°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- no further data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 1.22 mg/l
- No. of animals per sex per dose:
- 6 male rabbits
- Control animals:
- not specified
- Details on study design:
- no further data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 1.22 mg/L air
- Exp. duration:
- 1 h
- Remarks on result:
- other: no mortality; generelized inactivity, lacrimation; onset: 15-30 minutes; recovery at treatment day
- Mortality:
- no
- Clinical signs:
- other: generelized inactivity, lacrimation; onset: 15-30 minutes; recovery at treatment day
- Body weight:
- initial mean body weight: 197 g;
terminal mean body weight: 250 g. - Gross pathology:
- no significant findings
- Other findings:
- no further details
Any other information on results incl. tables
no further details
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Executive summary:
Exposure of male rats to the test substance for 1 hour amd post-exposure observation for clinical signs anf mortality resulted in no mortality: but generalized inactivity: LC50 >1.22 mg/L/1h air (Industrial Biotest Laboratories 1969).
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