Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
202-423-8
CAS no.:
95-48-7
Index number:
Molecular formula:
C7H8O
SMILES:
CC1=C(O)C=CC=C1
InChI:
InChI=1S/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
17
Of which contain:
5 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is toxic if swallowed, is toxic in contact with skin and causes severe skin burns and eye damage.

Breakdown of all 0 C&L notifications submitted to ECHA

Acute Tox. 3 H301 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 22 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates). Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles, mixing in open batch processes and non-industrial spraying.

Release to the environment of this substance can occur from industrial use: in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures and in processing aids at industrial sites. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: electrical batteries and accumulators. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates). Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following products: polymers, coating products and washing & cleaning products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, roller or brushing applications, treatment of articles by dipping and pouring, laboratory work and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites and in the production of articles.

This substance is used in the following products: polymers, coating products and fillers, putties, plasters, modelling clay. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, roller or brushing applications, treatment of articles by dipping and pouring and laboratory work.

Release to the environment of this substance can occur from industrial use: in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites, for thermoplastic manufacture and formulation of mixtures.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, transfer of substance into small containers and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • Afton Chemical S.P.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • BASF Italia S.p.A., Via Marconato 8 20811 Cesano Maderno Italy
  • Caplinq Europe BV, De Trompet 1126 1967 DA Heemskerk - Netherlands
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • DEZA a.s., Masarykova 753 75701 Valasske Mezirici Czech Republic
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Hexion B.V., Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands
  • Hexion GmbH, Varziner Str. 49 47138 Duisburg North Rhine-Westphalia Germany
  • Huntsman Advanced Materials (Europe) BVBA, Everslaan 45 B-3078 Everberg Belgium
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • Metinvest International Italia Srl - Ink, Via Antonio Salieri, 36 37050 Vallese di Oppeano (VR) Italy
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • RSI ChemRep Europe Ltd (K003), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RÜTGERS Germany GmbH, Kekulestr. 30 44579 Castrop-Rauxel Germany
  • Sasol UK Limited, Hockley Court, 2401 Stratford Rd Hockley Heath B94 6NW Solihull B94 United Kingdom
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • SI Group-UK, Ltd., Four Ashes WV 10 7BT Wolverhampton United Kingdom
  • Sojitz Europe PLC, Schirmerstrasse 76 40211 Dusseldorf Germany
  • UCP Chemicals AG, Stubenring 18 Top 5 1010 Vienna Vienna Austria
  • Vyncolit NV (OR DC), Wiedauwkaai 6 9000 Gent Belgium
  • Arcerion GmbH, Gabrielenstr. 15 80636 Muenchen Germany
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • [Confidential], [Confidential]

Substance names and other identifiers

3-hydroksytoluen (pl)
C&L Inventory
3-krezol (pl)
C&L Inventory
3-metylofenol (pl)
C&L Inventory
m-hydroksytoluen (pl)
C&L Inventory
m-krezol (pl)
C&L Inventory
m-metylofenol (pl)
C&L Inventory
o-cresol (da)
C&L Inventory
o-cresolo (it)
C&L Inventory
o-crésol (fr)
C&L Inventory
o-kreozolis (lt)
C&L Inventory
o-kresol (cs)
C&L Inventory
o-Kresoli (fi)
C&L Inventory
o-kresool (et)
C&L Inventory
o-krezol (hr)
C&L Inventory
o-krezols (lv)
C&L Inventory
o-methylphenol (da)
C&L Inventory
o-metilfenol (es)
C&L Inventory
o-κρεσόλη (el)
C&L Inventory
o-крезол (bg)
C&L Inventory
orto-krezol (sk)
C&L Inventory
Phenol, 2-methyl-
Other
2-methyl phenol
C&L Inventory
2-methyl-phenol
Registration dossier
2-METHYLPHENOL
C&L Inventory, Registration dossier, Other
Cresol
C&L Inventory
Cresol, ortho
Registration dossier
O -cresol
C&L Inventory
o-cresol;
C&L Inventory
ORTHO CRESOL
C&L Inventory
Ortho-cresol
Registration dossier
orthocresol
Registration dossier
1-HYDROXY-2-METHYLBENZOL
Registration dossier
2-CRESOL
Registration dossier
2-HYDROXYTOLUOL
Registration dossier
O-KRESOL 99
Registration dossier
o-Methyl-phenol
Registration dossier
O-METHYLPHENYLOL
Registration dossier
O-OXYTOLUOL
Registration dossier
604-004-00-9
Index number
C&L Inventory
95-48-7
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Crystalline (100%) [2]
C Odour
Other (100%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 2 studies processed
R Melting / freezing point
30.99 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
30.99 °C

Boiling point

Study results
  • 7 studies submitted
  • 3 studies processed
R Boiling point
191 °C @ 101.3 - 101.33 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
191 °C

Density

Study results
  • 8 studies submitted
  • 3 studies processed
R Density
1.05 g/cm³ @ 20 °C [1]
R Relative density
1.05 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.05

Vapour pressure

Study results
  • 8 studies submitted
  • 2 studies processed
R Vapour pressure
27 - 266 Pa @ 20 - 50 °C [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 4 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
37 Pa @ 25 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 2 studies processed
R Log Pow
1.95 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
1.95

Water solubility

Study results
  • 8 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
26 g/L @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
26 g/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 6 studies submitted
  • 1 study processed
R Flash point
81 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
81 °C

Auto flammability

Study results
  • 3 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
555 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
555 °C

Flammability

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 6
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 4 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (100%) [2]
R Dissociation constant
10.29 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
10.29

Viscosity

Study results
  • 3 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
3.06 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 6 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
9 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
9 h

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Study results
  • 2 studies submitted
  • 2 studies processed
R Dissipation Half-life (DT50)
24 - 264 h [6]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
11 days

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 17 studies submitted
  • 5 studies processed
R BOD5
2.16 g O2/g test material [2]
R COD
2.38 g O2/g test material [2]
C Interpretation of results
Readily biodegradable (50%), Inherently biodegradable (50%) [4]

Type of Study provided
Studies with data
Key study 8
Supporting study 8
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
5.1 days @ 20 °C

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
10.7

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
22

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
0.15 Pa m³/mol @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0.15 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 4.99 % [1]
R Water 93.68 % [1]
R Soil 0.66 % [1]
R Sediment 0.67 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 100 µg/L (1)
Intermittent releases (freshwater) 62 µg/L (1)
Marine water 10 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1.28 mg/L (1)
Sediment (freshwater) 580 µg/kg sediment dw (1)
Sediment (marine water) 58 µg/kg sediment dw (1)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 57.2 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning -

Short–term toxicity to fish

Study results
  • 24 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 6.2 - 7.2 mg/L [3]
LC50 (48 h) 7.2 - 8.6 mg/L [3]
LC50 (24 h) 7.2 - 9.9 mg/L [3]
LC50 (6 h) 11 - 14.1 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 11
Weight of evidence
Other 11 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
6.2 mg/L

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (32 days) 1.35 mg/L [2]
LOEC (32 days) 2.57 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
1.35 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 14 studies submitted
  • 2 studies processed
P/RResults
LC50 (48 h) 9.6 - 16.4 mg/L [6]

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other 6
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
9.6 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 1 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
1 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 11 studies submitted
  • 3 studies processed
P/RResults
EC50 (4 days) 100 mg/L [2]
EC50 (48 h) 75 mg/L [2]
NOEC (7 days) 6.8 mg/L [1]

Type of Study provided
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other 6
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater algae
6.8 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 18 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 6
Supporting study 3
Weight of evidence
Other 9
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
12.8 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.5 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 153 mg/m³ acute toxicity
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 680 µg/kg bw/day acute toxicity
Local Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
-
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 750 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 105 mg/m³ acute toxicity
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 250 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 340 µg/kg bw/day acute toxicity
Local Effects
Long-term: - -
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 250 µg/kg bw/day repeated dose toxicity
Acute /short term: - -
EYE Exposure
-

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence 3
Other 1 3
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 9 studies submitted
  • 2 studies processed
P/RResults
LD50 121 mg/kg bw (rat) [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 3 4
Data waiving
no waivers
inhalation
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study 7
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 7 studies submitted
  • 3 studies processed
P/RResults
LD50 890 - 1 380 mg/kg bw (rabbit) [3]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other 3 1
Data waiving
no waivers
other routes
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 5
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 121 mg/kg bw
Inhalation route:
No adverse effect observed Discriminating conc. 20 000 mg/m³
Dermal route:
Adverse effect observed LD50 890 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 5 1
Data waiving
no waivers
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2 2
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Repeated dose toxicity

Study results
Study data: oral
  • 10 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 50 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 6
Data waiving
no waivers
Study data: inhalation
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence 4
Other 4
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 21 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study 3
Weight of evidence
Other 11 3
Data waiving
no waivers
Study data: in vivo
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1 2
Supporting study 1
Weight of evidence
Other 2 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 1
Data waiving
no waivers
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Study data: other studies
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant