Registration Dossier
Registration Dossier
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EC number: 202-423-8 | CAS number: 95-48-7
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Remarks:
- additional investigations in female mice within a 28 day study
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: additional investigations in female mice within a 28 day study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Title:
- No information
- Author:
- US Department of Health and Human Sevices (1990/1991). NTP Report on the toxicity studies of cresols in F344/N rats and B6C3F1 mice (feed studies). NTP TOX 9, 1990/1991
Materials and methods
- Principles of method if other than guideline:
- Type: subacute study
Method: dose-finding study for a 13 week study - GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
- Details on test material:
- Test substance: o-cresol, purity
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 28 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1000, 3000, 10000, 30000 ppm
Basis:
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Duration of test: 28 d
Results and discussion
Any other information on results incl. tables
In histopathology:
30000 ppm: mild ovarian atrophy in 3/5 animals and in 4/5 moderate
uterine atrophy.
10000 ppm: in 5/5 animals mild uterine atrophy.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
