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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: in-vitro investigation

Data source

Reference
Reference Type:
publication
Title:
Permeability of human epidermis to the phenolic compounds
Author:
Roberts MS, Anderson RA, Swarbrick J
Year:
1977
Bibliographic source:
J Pharm Pharmac 29: 677-683

Materials and methods

Principles of method if other than guideline:
Epidermal membranes from human abdominal skin (2.5 cm²) were supported in a glass cell and the amount of m-cresol passsing to the receptor vessel was measured spectrophotometrically at room temperature. The test was conducted twice.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
o-cresol: not further specified
Radiolabelling:
no

Test animals

Species:
other: human epidermis in vitro
Sex:
not specified
Details on test animals or test system and environmental conditions:
in vitro study

Administration / exposure

Type of coverage:
other: in vitro study
Vehicle:
water
Duration of exposure:
up to 250 minutes
No. of animals per group:
in vitro study

Results and discussion

Any other information on results incl. tables

The permaeability coefficient of o-cresol was 2.62 x 10(exp)-4 cm/min and the lag time for a 0.4 %w/v solution was 15 min.

The threshold concentration for damage i.e. the aqueous concentration at which the permeability coefficient began to increase was 0.9 % w/v.

Applicant's summary and conclusion