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Description of key information

No reliable repeated-dose toxicity data are available for (3-chloropropyl)triethoxysilane, therefore good quality data for the analogous substance (3-chloropropyl)trimethoxysilane have been read-across.
In a 90-day inhalation study (DCC, 1993) in rats, conducted in accordance with OECD 413, the NOAEC was determined to be 100 ppm (813 mg/m3).
(3-Chloropropyl)trimethoxysilane was tested in an inhalation OECD 422 study (RCC, 2005), whole-body in rats, up to and including the highest concentration of 100 ppm. In this study there were no signs of general toxicity. Therefore based on these results the NOAEC was established to be at least 100 ppm (813 mg/m3).
A repeated application study via the dermal route is available for (3-chloropropyl)triethoxysilane. However, the purpose of this test was to determine irritation effects following repeated exposures, and did not meet the requirements for a repeated dose toxicity test.

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification