Registration Dossier

Administrative data

Description of key information

In the key in vivo skin and eye irritation studies for (3-chloropropyl)triethoxysilane (DCC, 1995c and DCC, 1995d), the substance was not irritant to rabbit skin or eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The key skin and eye irritation studies were selected as the only available studies for these endpoint that were carried out in accordance with the relevant OECD test guideline and GLP (reliability 1). A further study for each endpoint complying with an EPA guideline and GLP (also reliability 1) found mild and transient skin and eye irritation. Several non-guideline and/or non-GLP Reliability 2 studies (four in the case of skin irritation and three for eye irritation) were also available. All these studies supported the classification not irritant to the skin and eyes of the key studies.

Justification for classification or non-classification

Based on reliable in vivo skin and eye irritation data, (3 -chloropropyl)triethoxysilane does not meet the criteria for classification as irritant according to EU Directive 67/548/EEC and Regulation 1272/2008.