Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

The key sensitisation study was selected as the most recent guideline study available from four reliable tests (DCC, 1995e), and was therefore assigned Reliability 1. The key study, and two Reliability 2 supporting studies (Civo Toxicology, 1980 and Leuschner, 1976) were guinea pig maximisation tests. In addition, a Reliability 1 study using the Buehler method is available ( Hüls, 1980). All four studies gave clear negative results.


Migrated from Short description of key information:
In the key study for skin sensitisation, which was a guinea pig maximisation test carried out in accordance with OECD 406 and in compliance with GLP, (3-chloropropyl)triethoxysilane was not sensitising. No positive skin reactions were observed in the test group.

Justification for classification or non-classification

Based on reliable in vivo studies, (3 -chloropropyl)triethoxysilane is not classified as a skin sensitiser according to EU Directive 67/548/EEC and Regulation 1272/2008.

There are no data to suggest that the substance should be classified as a respiratory sensitiser.