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Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study did not meet the criteria of current guidelines for skin irritation testing.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test involved repeated application of 0.5 g undiluted test substance to shaved rabbit skin for 10 days (excluding weekends).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexamethylcyclotrisiloxane
EC Number:
208-765-4
EC Name:
Hexamethylcyclotrisiloxane
Cas Number:
541-05-9
Molecular formula:
C6H18O3Si3
IUPAC Name:
hexamethyl-1,3,5,2,4,6-trioxatrisilinane

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No detail available.

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL

- Amount(s) applied (volume or weight with unit): 0.5g

- Concentration (if solution): undiluted

Duration of treatment / exposure:
The test material was applied daily for 10 days (excluding weekends)
Observation period:
Data not available.
Number of animals:
1
Details on study design:
TEST SITE

- Area of exposure: abdomen

- Type of wrap if used: The application sites were then covered with a semi-occlusive dressing.

- The abdomen of the rabbit was prepared for testing by shaving the application site. One side of the abdomen was manually abraded while the skin on the opposite was not.  

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Remarks on result:
other: The test material produced slight redness only.
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Remarks on result:
other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Remarks on result:
other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
Irritant / corrosive response data:
The test material produced slight redness only.
Other effects:
No data available.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In the in vivo skin irritation study, not conducted according to OECD Test Guideline or in compliance with GLP, 10-day repeated application of hexamethylcyclotrisiloxane onto the intact or abraded rabbit skin produced only slight redness, which was not concluded to be sufficient evidence for irritation.