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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study did not meet the criteria of current guidelines for eye irritation testing.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
0.1 ml undiluted hexamethylcyclotrisiloxane were instilled onto both eyes of one rabbit, after which one eye was washed and the other was not. The eyes were observed at 1, 2, 24, 48 and 168 hours.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexamethylcyclotrisiloxane
EC Number:
208-765-4
EC Name:
Hexamethylcyclotrisiloxane
Cas Number:
541-05-9
Molecular formula:
C6H18O3Si3
IUPAC Name:
hexamethyl-1,3,5,2,4,6-trioxatrisilinane

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available.

Test system

Vehicle:
not specified
Controls:
no
Amount / concentration applied:
TEST MATERIAL

- Amount(s) applied (volume or weight with unit): 0.1 ml

- Concentration (if solution): undiluted


Duration of treatment / exposure:
Single instillation into both eyes, after which one eye was washed and the other was not.
Observation period (in vivo):
The eyes were observed for 1, 2, 24, 48 and 168 hours.
Number of animals or in vitro replicates:
1
Details on study design:
No data available.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: not stated
Score:
0
Max. score:
4
Remarks on result:
other: No eye irritation was observed. The test material was not an eye irritant.
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
iris score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
iris score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
iris score
Basis:
animal #3
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
24/48/72 h
Remarks on result:
other: Individual irritation scores were not available.
Irritant / corrosive response data:
Individual irritation scores were not available. No eye irritation was observed. The test material was not an eye irritant.
Other effects:
No data available.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In the in vivo eye irritation study, not conducted according to OECD Test Guideline or in compliance with GLP, no eye irritation was observed and the test material was concluded to be not irritating to eyes.