Protein hydrolyzates, vegetable

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is unlikely to cross biological membranes, hence indicating that aquatic toxicity is unlikely to occur

Justification for type of information:

The plasma membrane of a mammalian cell is an intricate composite of multiple lipid and protein species continually undergoing endocytosis and exocytosis. Whereas small molecules with moderate polarity are able to diffuse through the cell membrane passively, most metabolites and short peptides require specialized membrane transporters for translocation. Proteins are generally unable to cross the cell membrane, with protein toxins being exceptions where sophisticated (and yet to be fully elucidated) mechanisms have been evolved for translocation.