Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Justification for type of information:
It is well known that hydrolysis of cell proteins requires the degradation of cell wall. This degradation is enhanced due to the enzymatic or acidic action. Therefore, penetration of protein hydrolysates inside the cell through the wall without an external aid is very unlikely:

It is unlikely that peptides will passively diffuse across the cell membrane, but altering their physical properties (such as conformational flexibility and polarity) has been proposed to improve their permeability. Despite interesting findings—a selection of which is discussed in the following—conflicting experimental results have been reported. A straightforward method for converting a non-permeable peptide into an efficiently permeating entity is thus
not available so far.

Proteins cannot passively diffuse across the cell membrane due to their size and polarity. Thus, a delivery system or technique is always required, similar to nucleic acid transfection.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion