Registration Dossier
Registration Dossier
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EC number: 214-946-9 | CAS number: 1222-05-5
Endpoint summary
Administrative data
Description of key information
Overview of short and long-term aquatic toxicity studies for HHCB in fresh and marine water
Test species | Guideline | Results (mg/L) | Remarks |
Short-term |
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Pseudokirchneriella subcapitata | OECD TG201 | 72h-ErC50> 0.854 (mean measured concentrations) | Key study, K1 Van Dijk 1997 |
Daphnia magna | OECD TG202 | 48h EC50 = 0.194 (nominal; measured concentrations are ca. 100% of nominal) | Key study, K2 Chen et al. 2015 |
Oryzias latipes (larvae) | similar to OECD TG 203 | 96h-LC50 = 0.95 semi-static (nominal concentrations) | Key study, K2 Yamauchi et al. 2008 |
Long-term |
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Pseudokirchneriella subcapitata | OECD TG201 | 72h-NOEC = 0.201 (mean measured) | Key study, K1 Van Dijk 1997 |
Daphnia magna | OECD TG211 | 21d-NOECrep = 0.111 21d-EC50rep = 0.282 21d-EC50(immob) = 0.293 semi-static (mean measured concentrations) | Key study, K1 Wüthrich 1996a |
Pimephales promelas | OECD TG210 | 36d-NOEC= 0.068 based on survival, growth & development 36d-LC50 >0.140 (mean measured concentration) | Key study, K1 Croudace 1997 |
Microorganisms | OECD TG301D | 5d-NOEC = 10 | Key study, K2 Jenkins, 1991 |
Marine water
Test species | Guideline | Results (mg/l) | Remarks |
Short-term - invertebrates |
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Acartia tonsa | OECD TG 202 | 48h-EC50: 0.47 (nominal concentrations) | Key study, Kl. 2 Wollenberger et al. 2003 |
Long-term - invertebrates |
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Acartia tonsa | Draft OECD guideline* | 6d-EC10 development: 0.044 6d-NOEC development: 0.038 6d-EC50 development: 0.131 With radiolabel and nominal concentrations used. | Key study, Kl. 2 Bjornstad, 2007 |
For Acartia the testing procedure is an OECD draft guideline (2013):Harpacticoid Copepod Development and Reproduction Test with Amphiascus tenuiremis: https://www.oecd.org/env/ehs/testing/OECD%20TG%20Harpacticoid%20Copepod_Draft%20for%20REVIEW_15%20July%202013.pdf
Additional information
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