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Description of key information

Overview of short and long-term aquatic toxicity studies for HHCB in fresh and marine water


































































Test species



Guideline



Results (mg/L)



Remarks



Short-term



 



 



 



Pseudokirchneriella subcapitata



OECD TG201



72h-ErC50> 0.854


(mean measured concentrations)



Key study, K1


Van Dijk 1997



Daphnia magna



OECD TG202



48h EC50 = 0.194


(nominal; measured concentrations are ca. 100% of nominal)



Key study, K2


Chen et al. 2015



Oryzias latipes (larvae)



similar to OECD TG 203



96h-LC50 = 0.95 


semi-static


(nominal concentrations)



Key study, K2


Yamauchi et al. 2008



Long-term



 



 



 



Pseudokirchneriella subcapitata



OECD TG201



72h-NOEC = 0.201 


(mean measured)



Key study, K1


Van Dijk 1997



Daphnia magna



OECD TG211



21d-NOECrep = 0.111


21d-EC50rep = 0.282 


21d-EC50(immob) = 0.293  


semi-static (mean measured concentrations)



Key study, K1


Wüthrich 1996a



Pimephales promelas



OECD TG210



36d-NOEC= 0.068 based on


survival, growth & development


36d-LC50 >0.140


(mean measured concentration)



Key study, K1


Croudace 1997



Microorganisms



OECD TG301D



5d-NOEC = 10



Key study, K2


Jenkins, 1991



 


Marine water




































Test species



Guideline



Results (mg/l)



Remarks



Short-term - invertebrates



 



 



 



Acartia tonsa



OECD TG 202



48h-EC50: 0.47


(nominal concentrations)



Key study, Kl. 2


Wollenberger et al. 2003



Long-term - invertebrates



 



 



 



Acartia tonsa



Draft OECD guideline*



6d-EC10 development: 0.044


6d-NOEC development: 0.038


6d-EC50 development: 0.131


With radiolabel and nominal concentrations used.



Key study, Kl. 2


Bjornstad, 2007



For Acartia the testing procedure is an OECD draft guideline (2013):Harpacticoid Copepod Development and Reproduction Test with Amphiascus tenuiremis:  https://www.oecd.org/env/ehs/testing/OECD%20TG%20Harpacticoid%20Copepod_Draft%20for%20REVIEW_15%20July%202013.pdf   


 

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