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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Oral LD50 data in rats: 1 study on the registered substance, LD50 >2000 mg/kg

Dermal LD50 in rabbits >2000 mg/kg (on a compenant of the registered substance substance)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
3 540 mg/kg bw

Additional information

An acute oral toxicity study performed in rats on the registered substance, the acute oral LD50 ofwas determined to be greater than 2000 mg/kg/bw.

The vapour pressure for 2 -(2 -(2-butoxyethoxy)ethoxy)ethanol is so low that no exposure is likely via the inhalation route and therefore no hazard would be expected by the inhalation route , bearing in mind the low toxicity by other routes.

In an acute dermal toxicity in rabbits, an LD50 of 3540mg/kg was obtain for the similar substance 2 -(2 -(2-butoxyethoxy)ethoxy)ethanol. Exposure was under occluded conditions. Information available suggests the dose response curve is unusually shallow. The data suggests significant absorption potential through skin but that absorption is <100%.

Read across is justified since toxicity decreases with increasing molecular weight within a given alkyl homologous series so the lowest molecular weight major component of this substance, (2 -(2 -(2 -butoxyethoxy)ethoxy)ethanol, is likely to be the most toxic (or in this case the "least non-toxic") component and data from it can be considered as a conservative surrogate for the toxicity of the UVCB substance "Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy" as a whole, as is the case for dermal toxicity.

Justification for classification or non-classification

The LD50 by the dermal route and the oral route are greater than the cut off dose of 2000mg/kg and therefore classification is not required. No adverse effects are seen following inhalation exposure to saturated vapour concentrations and therefore no classification by this route is required.