Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Principles of method if other than guideline:
The acute toxicity of SBP 100/140 was determined according to Noakes and Sanderson (1969): A method for determining the dermal toxicity of pesticides, Br. J. Industr Med 26: 59-64.
GLP compliance:
no
Test type:
other: according to Noakes and Sanderson (1969), Br. J. Industr Med 26: 59-64

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): SBP 100/140
- Analytical purity: 100% pure commercial product
- Composition of test material, percentage of components: low aromatic content solvent consisting of about 35% C7, 50% C8 and 15% C9 saturated hydrocarbon isomers

Test animals

Species:
rat
Strain:
other: Charles River CD
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Charles River (UK) Ltd., Manston, Kent

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
1, 2, 4 mL/kg
No. of animals per sex per dose:
2
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 4 mL/kg bw
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 800 - 3 100 mg/kg bw
Remarks on result:
other: Recalculated values based on the LD50 of 3.16 mL/kg bw; the range of LD50 is due to the range of density 0.71 -0.78 g/cm3.
Mortality:
none
Clinical signs:
none

Any other information on results incl. tables

Table: Mortality

Dose ml/kg

Males

Female

Total

1

0/2

0/2

0/4

2

0/2

0/2

0/4

4

0/2

0/2

0/4

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: CLP
Conclusions:
The dermal toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was examined. Groups of two female and two male rats were exposed dermally to 1, 2, or 4 mL/kg of test substance. No animals died during the experiment. The dermal LD50 for rats is >= 4 mL/kg. The test substance is not classified as a dermal toxic under OECD GHS guidelines.
Executive summary:

The dermal toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was examined. Groups of two female and two male rats were exposed dermally to 1, 2, or 4 mL/kg of test substance. No animals died during the experiment. The dermal LD50 for rats is >= 4 mL/kg. The test substance is not classified as a dermal toxic under OECD GHS guidelines.