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EC number: 921-024-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Oral LD50 (rat) > 5840 mg/Kg bw
Inhalation LC50 (rat) > 25200 mg/m³
Dermal LD50 (rat) > 2800 -3100 mg/Kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Principles of method if other than guideline:
- standard acute oral test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd., Manston, Kent
- Age at study initiation: approx. 12 weeks
- Fasting period before study: on night before test
- Housing: 4 animals of one sex in a cage
- Diet (e.g. ad libitum): ad libitum after dosing
- Water (e.g. ad libitum): ad libitum after dosing - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1, 2, 4, and 8 mL/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 9 days
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 8 mL/kg bw
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 8 mL/kg bw
- Mortality:
- No mortality occurred in any test animal over the 9-day observation period.
- Interpretation of results:
- other: Not Classified
- Remarks:
- Criteria used for interpretation of results: EU, GHS
- Conclusions:
- The purpose of this study was to determine the acute oral toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics. Two male and two female rats were exposed to 1, 2, 4, or 8 mL/kg of undiluted test substance orally. The animals were then observed for the next 9 days for mortality. No animals of either sex died during the study. The LD50 is > 8 mL/kg for both male and female rats. Based on the density given in the study report, the LD50 is calculated to approx. >5840 mg/kg bw. The test substance is not classified according to OECD GHS guidelines.
- Executive summary:
The purpose of this study was to determine the acute oral toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics. Two male and two female rats were exposed to 1, 2, 4, or 8 mL/kg of undiluted test substance orally. The animals were then observed for the next 9 days for mortality. No animals of either sex died during the study. The LD50 is > 8 mL/kg for both male and female rats. Based on the density given in the study report, the LD50 is calculated to approx. >5840 mg/kg bw. The test substance is not classified according to OECD GHS guidelines.
Reference
Based on the density given in the study report, the LD50 is calculated to approx. >5840 mg/kg bw
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 5 840 mg/kg bw
- Quality of whole database:
- One key read across study from structural analogue available for assessment.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 Sep 1987 - 22 Sep 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
- Principles of method if other than guideline:
- Group of rats were exposed to test substance vapour for four hours and LC50 was determined.
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Limited
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 200 g
- Housing: polypropylene cages (38x56x18 cm)
- Diet: free access to a measured excess amount of food
- Water (ad libitum): tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21±0.8 - 25±1.3
- Humidity (%): 61±6.6 - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: vapour generator plus exposure chamber
- Exposure chamber volume: 120 L
- Method of holding animals in test chamber: wire mesh compartments
- Source and rate of air: supply of clean dried air was connected to the generator and the supply pressure was adjusted to give a flow rate of 25 L per minute
- Temperature in air chamber: 25±0.33-25.9 °C
TEST ATMOSPHERE
- Brief description of analytical method used: analysed with a gas chromatograph. Samples were drawn through a gas absorption trap, containing 20 ml of acetone and cooled to -70 °C. Sampling rate was 2 litres/minute and the volume of air sample was measured with a wet-type gas meter.
- Samples taken from breathing zone: yes
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Pye Unicam PU 4550 fitted with a flame ionisation detector. Pye Unicam PU 4700 autosampler.
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 25.2 mg/L air
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs at least twice daily, body weight daily, food and water consumption daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights - Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 25.2 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: restless behavior and increase in respiration rate during the first 15 minutes; partial closing of the eyes
- Body weight:
- no effects
- Gross pathology:
- The lung weight to bodyweight ratio for all rats was considered to be within normal limits. No other macroscopic abnormalities were observed.
- Other findings:
- Food consumption was slightly reduced for 1 day following exposure. Water consumption was not affected by exposure.
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of the study a 4 hour LC50 >25.2 mg/L air was determined for the test substance, hydrocarbons, C6-C7, n-alkanes, Isoalkanes, cyclics < 5% hexane.
- Executive summary:
Under the conditions of the study a 4 hour LC50 >25.2 mg/L air was determined for the test substance, hydrocarbons, C6-C7, n-alkanes, Isoalkanes, cyclics, < 5% n-hexane.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- > 25 200 mg/m³ air
- Quality of whole database:
- One substance specific key study available for assessment.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Principles of method if other than guideline:
- The acute toxicity of SBP 100/140 was determined according to Noakes and Sanderson (1969): A method for determining the dermal toxicity of pesticides, Br. J. Industr Med 26: 59-64.
- GLP compliance:
- no
- Test type:
- other: according to Noakes and Sanderson (1969), Br. J. Industr Med 26: 59-64
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd., Manston, Kent - Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 1, 2, 4 mL/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 4 mL/kg bw
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 800 - 3 100 mg/kg bw
- Remarks on result:
- other: Recalculated values based on the LD50 of 3.16 mL/kg bw; the range of LD50 is due to the range of density 0.71 -0.78 g/cm3.
- Mortality:
- none
- Clinical signs:
- other: none
- Interpretation of results:
- other: Not Classified
- Remarks:
- Criteria used for interpretation of results: other: CLP
- Conclusions:
- The dermal toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was examined. Groups of two female and two male rats were exposed dermally to 1, 2, or 4 mL/kg of test substance. No animals died during the experiment. The dermal LD50 for rats is >= 4 mL/kg. The test substance is not classified as a dermal toxic under OECD GHS guidelines.
- Executive summary:
The dermal toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was examined. Groups of two female and two male rats were exposed dermally to 1, 2, or 4 mL/kg of test substance. No animals died during the experiment. The dermal LD50 for rats is >= 4 mL/kg. The test substance is not classified as a dermal toxic under OECD GHS guidelines.
Reference
Table: Mortality
Dose ml/kg |
Males |
Female |
Total |
1 |
0/2 |
0/2 |
0/4 |
2 |
0/2 |
0/2 |
0/4 |
4 |
0/2 |
0/2 |
0/4 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 800 - < 3 100 mg/kg bw
- Quality of whole database:
- One key read across study from structural analogue available for assessment.
Additional information
There is one substance specific acute inhalation data available for Hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane. Additionally, data is available for structural analogue, Hydrocarbons, C7 -C9, n-alkanes, isoalkanes, cyclics and is presented in the dossier. This data is read across to Hydrocarbons, C6 -C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
Acute Oral Toxicity
Hydrocarbons, C7 -C9, n-alkanes, isoalkanes, cyclics
In a key study (Shell, 1977) the acute oral toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was determined. Two male and two female rats were exposed to 1, 2, 4, or 8 mL/kg of undiluted test substance orally. The animals were then observed for the next 9 days for mortality. No animals of either sex died during the study. The LD50 is > 8 mL/kg for both male and female rats. Based on the density given in the study report, the LD50 is calculated to approx. >5840 mg/kg bw. The test substance is not classified according to OECD GHS guidelines.
Acute lnhalation Toxicity
Hydrocarbons, C6 -C7, n-alkanes, isoalkanes, cyclics, <5% hexane
In a key study (Sell, 1988), the acute inhalation toxicity of hydrocarbons, C6 -C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane was deteremined. Five male and five female rats were exposed to the test substance for 4 hours. Clinical signs, bodyweight, food and water consumption were recorded at least once daily. Necropsy of survivors was performed. Under the conditions of the study a 4 hour LC50 >25.2 mg/L air was determined for the test substance, hydrocarbons, C6-C7, n-alkanes, Isoalkanes, cyclics, < 5% n-hexane.
Acute Dermal Toxicity
Hydrocarbons, C7 -C9, n-alkanes, isoalkanes, cyclics
In a key study (Shell, 1977), dermal toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was examined. Groups of two female and two male rats were exposed dermally to 1, 2, or 4 mL/kg of test substance. No animals died during the experiment. The dermal LD50 for rats is >= 4 mL/kg. The test substance is not classified as a dermal toxic under OECD GHS guidelines.
Justification for classification or non-classification
Based on available substance specific and read across data, Hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane is minimally toxic via ingestion where the LD50 is >5840 mg/kg, via dermal exposure where the LD50 is >2800 -3100 mg/kg, and by inhalation where the LC50 >25200 mg/m3. These findings are conclusive but not sufficient for classification. However, acute exposure may result in non-lethal narcotic effects and the substance is therefore classified as STOT-SE Category 3 for narcosis effects under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane is classified under EU CLP guidelines as a Category 1 aspiration hazard based on its physical and chemical properties (hydrocarbon fluid, viscosity ≤ 20.5 mm2/s).
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