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EC number: 200-898-6 | CAS number: 75-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: 7 days
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer-reviewed data, reliability according to US-EPA IUCLID data set.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- HPVIS, IUCLID Data Set for Methanesulphonic acid, CAS no. 75-75-2
- Author:
- US-EPA
- Year:
- 2 006
- Bibliographic source:
- HPV Chemicals Challenge Program OPPT CBIC 201-16750B
- Reference Type:
- review article or handbook
- Title:
- Methanesulfonic acid.
- Author:
- Shertzer HG
- Year:
- 2 001
- Bibliographic source:
- Patty's Toxicology, 5th edition, Vol 7, Ch. 94: 745-746
Materials and methods
- Principles of method if other than guideline:
- Four groups of 3-5 rats were fed diet containing Methanesulphonic acid (MSA) for 7 days at the target dose levels of 50, 200, 500 and 2000 mg/kg bw. Control animals received normal diet. Clinical signs, body weight and food consumption was determined.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): Methane sulfonic acid
- Physical state: liquid, mixed with food
- Analytical purity: 98 % anhydrous state
- Lot/batch No.: 8E29
- Other: Source: MCB, South Charleston, WV.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Industries, Cumberland
- Age at study initiation: 30 days
- Weight at study initiation: 84 - 147g (males), 79 - 130 g (females)
- Fasting period before study: unfasted
- Housing: 2 or 3 per cage
- Diet: ad libitum
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- water
- Details on oral exposure:
- PREPARATION OF DOSING SOLUTIONS:
Dilution with distilled water, then mixed with food - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- continuously
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
males 51, 185, 420, 1805 mg/kg bw/d; females: 55, 201, 551, 2122 mg/kg bw/d
Basis:
actual ingested
- Remarks:
- Doses / Concentrations:
males: 0.043, 0.159, 0.382, 1.635 %; females: 0.045, 0.183, 0.479, 1.80 %
Basis:
nominal in diet
- No. of animals per sex per dose:
- 5 (except 3/lower dose)
- Control animals:
- yes, plain diet
Examinations
- Observations and examinations performed and frequency:
- DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: at least once per day
BODY WEIGHT: Yes
- Time schedule for examinations: three times during the week
FOOD CONSUMPTION: Yes (no data concerning frequency)
WATER CONSUMPTION: No data
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: No
CLINICAL CHEMISTRY: No
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No data - Sacrifice and pathology:
- GROSS PATHOLOGY: yes
HISTOPATHOLOGY: No - Other examinations:
- Mortality (at least twice a day), Liver and kidney weight (absolute and relative)
- Statistics:
- The results of weight changes were intercompared for the dosage groups by use of Bartlett's test for homogeneity of variance, by the analysis of variance and by Duncan's multiple range test. The latter was used, if F for the analysis of variance was significantly high, to delineate which groups differed from the others. If Bartlett's test indicated heterogeneous variances, the F-test was used for any paired-group comparison. If these individual F-tests were not significant, Student's t-test was used; if significant, the means were compared by the Cochran t-test. The fiducial limit of 0.05 was employed as the critical level of difference not believed to be produced by chance.
Results and discussion
Results of examinations
- Details on results:
- CLINICAL SIGNS AND MORTALITY
No mortality.
BODY WEIGHT AND WEIGHT GAIN
No significant variation.
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study)
No significant variation in food consumption. The compound intake for males in the target dose levels of 0, 50, 200, 500 and 2000 mg/kg bw were 51, 185, 420, 1805 mg/kg bw/d, respectively. The compound intake for females in the target dose levels of 0, 50, 200, 500 and 2000 mg/kg bw were 55, 201, 551, 2122 mg/kg bw/d, respectively.
ORGAN WEIGHTS
No relevant changes.
GROSS PATHOLOGY
Findings not reported.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 805 mg/kg bw/day (actual dose received)
- Sex:
- male
- Dose descriptor:
- NOAEL
- Effect level:
- >= 2 122 mg/kg bw/day (actual dose received)
- Sex:
- female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
None of the rats orally exposed to methane sulfonic acid (up to 2122 mg/kg bw/day) died during this 7-day study. Furthermore, none of the measured parameters was affected by the exposure.
Additionally, the potassium salt of methane sulfonic acid was investigated in this study up to 2080 mg/kg bw/day without effects, as well.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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