Registration Dossier
Registration Dossier
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EC number: 200-898-6 | CAS number: 75-75-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
- Reference Type:
- publication
- Title:
- HPVIS, IUCLID Data Set for Methanesulphonic acid, CAS no. 75-75-2
- Author:
- US-EPA
- Year:
- 2 003
- Bibliographic source:
- HPV Chemicals Challenge Program OPPT NCIC 201-14249B
Materials and methods
- Principles of method if other than guideline:
- Atmospheric saturation was obtained by placing 1.36 ml of the sample in an airtight twenty-litre chamber and allowing 24h for evaporation. The chamber was then momentarily opened to permit the quick insertion of mice. Exposure was terminated 1 h later and the animals were observed for 7 days.
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): Methanesulphonic acid
- Physical state: vapour
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 32 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: airtight chamber
- Exposure chamber volume: 20 L
- Method of holding animals in test chamber: not restrained - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- Saturated vapor (at 20°C), analytical concentration not determined.
Saturated vapor calculated based on molecular weight and vapor pressure is 0.00188 mg/l = 1.88 mg/m3. - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
- Other examinations performed: clinical observations, body weight
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- > 1.88 mg/m³ air
- Exp. duration:
- 1 h
- Remarks on result:
- other: inhalation hazard test
- Mortality:
- No mortality.
- Clinical signs:
- other: No effects were discernible during or after the exposure.
- Body weight:
- Normal gains in body weight during the subsequent 7-day observation period.
- Gross pathology:
- Not performed.
Any other information on results incl. tables
Conclusion: Insufficient volatility of methane sulfonic acid limits the actual exposure and therefore toxicity risks.
Applicant's summary and conclusion
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