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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented analytical results, data generated under the National Health and Nutrition Examination Survey

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2010

Materials and methods

Type of study / information:
data on background urine levels of arsenic and its compunds
Endpoint addressed:
other: urine background level
Principles of method if other than guideline:
analytical investigation
GLP compliance:
yes
Remarks:
data generation under government control

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Ethical approval:
not applicable

Results and discussion

Results:
Well documented analytical results were generated under the National Health and Nutrition Examination Survey. 2005 to 2006 the background levels of Arsenic Total, Arsenic(V) acid, Arsenbetaine, Arsencholine, Arsenous (III) acid, Dimethylarsinic acid, Monomethylarsonic acid and Trimethylarsine acid were determined in human urine.
The geometric mean of the creatinine corrected total Arsenic content was: 9.15 µg/g of creatinine, maximum levels were found with non-hispanic blacks, here the upper limit of the 95th percentile confidence interval was 120 µg/g of creatinine.

Applicant's summary and conclusion

Conclusions:
2005 to 2006 the background levels of Arsenic Total, Arsenic(V) acid, Arsenbetaine, Arsencholine, Arsenous (III) acid, Dimethylarsinic acid, Monomethylarsonic acid and Trimethylarsine acid were determined in human urine.
Total Arsenic (creatinine corrected) geometric mean: 9.15 µg/g of creatinine,
maximum levels: 95th percentile confidence interval of non-hispanic blacks: 120 µg/g of creatinine.
Executive summary:

Well documented analytical results, data generated under the National Health and Nutrition Examination Survey. In the years 2005 to 2006 the background urine levels of Arsenic Total, Arsenic(V) acid, Arsenbetaine, Arsencholine, Arsenous (III) acid, Dimethylarsinic acid, Monomethylarsonic acid and Trimethylarsine acid were determined. The geometric mean of the creatinine corrected total Arsenic content was: 9.15 µg/g of creatinine, maximum levels were found with non-hispanic blacks, here the upper limit of the 95th percentile confidence interval was 120 µg/g of creatinine.