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Description of key information

Only the review article an human pulmonary alveolar proteinosis (Trapnell et al., 2003) is reliable with restrictions, the other 8 studies are not reliable.
Human pulmonary alveolar proteinosis is a disorder in which lipoproteinaceous material accumulates within alveoli.
Recent studies led to the concept that human acquired pulmonary alveolar proteinosis is an autoimmune disease targeting granulocyte-macrophage colony-stimulating factor (GM-CSF). A neutralizing autoantibody against GM-GSF causes defects in the functioning of alveolar macrophages, including impairment of the catabolism of surfactant lipids and proteins and disruption of surfactant homeostasis. No correlation to an exposure of gallium arsenide was found.

Additional information

The review article on human pulmonary alveolar proteinois (Trapnell et al., 2003) is reliable with restrictions. The other 8 studies on specific effects of GaAs such as: magnetometry, urine porphyrines, morphometry and cytochemistry are not reliable. Therefore they are disregarded.

The review article on human alveolar proteinosis revealed no association of the disease with an exposure to GaAs.

Human pulmonary alveolar proteinosis is a disorder in which lipoproteinaceous material accumulates within alveoli. An important feature of the disease is susceptibility to pulmonary infections, sometimes with opportunistic organisms. Recent studies led to the concept that human acquired pulmonary alveolar proteinosis is an autoimmune disease targeting granulocyte-macrophage colony-stimulating factor (GM-CSF). A neutralizing autoantibody against GM-GSF causes defects in the functioning of alveolar macrophages, including impairment of the catabolism of surfactant lipids and proteins and disruption of surfactant homeostasis.