Registration Dossier
Registration Dossier
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EC number: 203-438-2 | CAS number: 106-88-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given, comparable to guideline/standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standards
- GLP compliance:
- no
Test material
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- Body weight of female rabbit: 2.7 kg, body weight of male rabbit: 2.71 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- 0.05 ml
- Duration of treatment / exposure:
- 20 hours
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 days
- Score:
- 0
Any other information on results incl. tables
| Findings after | ||
| 1 hour | 24 hours | 8 days |
| slight reddening, slight edema, secretion | slight reddening, edema and cloudiness, smeary stratification | no findings |
NaCl solution showed no eye irritation.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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