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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
dynamic inhalation method with analytical and nominal determination of the concentration.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-epoxybutane
EC Number:
203-438-2
EC Name:
1,2-epoxybutane
Cas Number:
106-88-7
Molecular formula:
C4H8O
IUPAC Name:
oxolane
Test material form:
liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: WIGA Sulzfeld, Germany
- Age at study initiation: no data
- Weight at study initiation: 185 +/- 15 g
- Housing: no data
- Diet: ad libitum, Standard diet
- Water: ad libitum
- Acclimation period: no data

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
other: unchanged (no vehicle)
No. of animals per sex per dose:
10
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The body weight of the animals were checked before starting of the study, after 7 days and at the end of the observation period. Clinical signs and mortality were checked daily.
- Necropsy of survivors performed: yes; After the 14-day observation period the animals were killed and a pathological-anatomical evaluation was done.
Statistics:
none

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 6.3 mg/L air (analytical)
Mortality:
none
Clinical signs:
other: no symptoms
Body weight:
No significant differences regarding body weight growth in comparison to the air control group (see table)
Gross pathology:
nothing abnormal detected

Any other information on results incl. tables

Absolute body weight growth:










































































 Mean body weight before starting    after 7 days    after 14 days   
  males females males females males females

 Group 1


      
 Body weight in g 185 178 219 190 258 206
 No. of animals 10 10 10 10 10 10
 Control      
 Body weight in g 178 180 219 190 254 210
 No. of animals 10 10 10 10 10 10

 


Relative body weight growth:










































































 Mean body weight before starting    after 7 days    after 14 days   
  males females males females males females

 Group 1


      
 Body weight in g 0 0 34 12 73 28
 No. of animals 10 10 10 10 10 10
 Control      
 Body weight in g 0 0 41 10 76 30
 No. of animals 10 10 10 10 10 10

 


 

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met