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Key value for chemical safety assessment

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Ohnishi (1993) concluded: PpO and BtO are not known to produce neuropathy in humans; however, both produced ataxia of the hindleg and distal axonal degeneration of myelinated fibers of the lumbosacral primary sensory neuron in rats. Therefore, both must be considered to be neurotoxic. Although the concentration of PpO and BtO needed to produce neuropathy in rats is much greater than the exposure limits (100 ppm for PpO and not determined for BtO) recommended by the National Institute of Occupational Safety and Health, PpO and BtO may cause neuropathies in exposed workers.

Justification for classification or non-classification

Recognition of the neurotoxicity of both chemicals seems to be very important for better understanding the relationship between the chemicals and the distribution of morphologic alterations of the lumbosacral primary sensory neuron, one of the most vulnerable targets of the neurotoxic substances (Thomas, 1980).